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1.
FIG. 6.

FIG. 6. From: MicroRNA Expression and Virulence in Pandemic Influenza Virus-Infected Mice .

The r1918 might potentially regulate the cellular microRNA expression at multiple levels.

Yu Li, et al. J Virol. 2010 March;84(6):3023-3032.
2.
FIG. 3.

FIG. 3. From: MicroRNA Expression and Virulence in Pandemic Influenza Virus-Infected Mice .

Schematic representation of the strategy for assessing the functional associations of the differentially expressed microRNAs. A rectangular shape represents the type of microRNA, gene, or pathway. A diamond shape represents the type of database. An oval shape represents the type of analysis.

Yu Li, et al. J Virol. 2010 March;84(6):3023-3032.
3.
FIG. 2.

FIG. 2. From: MicroRNA Expression and Virulence in Pandemic Influenza Virus-Infected Mice .

A total of 18 microRNAs demonstrate various expression patterns between r1918-infected and Tx/91-infected lungs. All fold changes shown here are relative to mock-infected lungs. A red bar indicates an r1918 infection, and a blue bar indicates a Tx/91 infection.

Yu Li, et al. J Virol. 2010 March;84(6):3023-3032.
4.
FIG. 5.

FIG. 5. From: MicroRNA Expression and Virulence in Pandemic Influenza Virus-Infected Mice .

miR-223 is implicated in the CREB signaling pathway. (Top) CREB pathway comprised of miR-223 targets; (bottom) expression changes of miR-223 and its targets associated with the CREB pathway in r1918-infected samples. Red represents microRNA or targets that have increased expression in r1918-infected samples, relative to Tx/91-infected samples. Green represents microRNA or targets that have decreased expression in r1918-infected samples, relative to Tx/91-infected samples.

Yu Li, et al. J Virol. 2010 March;84(6):3023-3032.
5.
FIG. 4.

FIG. 4. From: MicroRNA Expression and Virulence in Pandemic Influenza Virus-Infected Mice .

miR-200a is implicated in the type I interferon signaling pathway. (Top) Type I interferon signaling pathway comprised of miR-200a targets; (bottom) expression changes of miR-200a and its targets associated with the type I interferon pathway in r1918-infected samples. Red represents microRNA or targets that have increased expression in r1918-infected samples, relative to Tx/91-infected samples. Green represents microRNA or targets that have decreased expression in r1918-infected samples, relative to Tx/91-infected samples.

Yu Li, et al. J Virol. 2010 March;84(6):3023-3032.
6.
FIG. 1.

FIG. 1. From: MicroRNA Expression and Virulence in Pandemic Influenza Virus-Infected Mice .

The infections of H1N1 influenza viruses r1918 and Tx/91 induce distinct cellular microRNA expression patterns in mouse lungs. (a) Distinct cellular microRNA expression patterns in r1918- and Tx/91-infected mouse lungs. The columns correspond to the expression patterns of differentially expressed microRNAs between r1918- and Tx/91-infected mouse lungs on days 1, 3, and 5. The y axis indicates the number of differentially expressed microRNAs. The microRNAs satisfied a cutoff ANOVA P value of ≤0.01 of direct comparison and the absolute fold change between r1918 and Tx/91 of ≥1.5. Red represents microRNA with increased expression in r1918- or Tx/91-infected samples, relative to mock-infected samples. Green represents microRNA with decreased expression in r1918- or Tx/91-infected samples, relative to mock-infected samples. (b) Correlation coefficient of microRNA expression changes derived from microRNAs arrays and TaqMan qRT-PCR assays. Each spot represents one microRNA per time point measurement. The x axis represents the fold change in r1918-infected samples relative to Tx/91-infected samples derived from microRNA arrays. The y axis represents the fold change in r1918-infected samples relative to Tx/91-infected samples derived from TaqMan qRT-PCR assays. The overall correlation coefficient is represented by the R2 value. A total of 8 microRNAs from the three days were tested. One spot represents three biological duplicates.

Yu Li, et al. J Virol. 2010 March;84(6):3023-3032.

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