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Results: 6

1.
Fig. 1

Fig. 1. From: Design and validation of a clinical instrument for spectral diagnosis of cutaneous malignancy.

(Color online) Schematic representation of spectral diagnosis system.

Narasimhan Rajaram, et al. Appl Opt. ;49(2):142-152.
2.
Fig. 2

Fig. 2. From: Design and validation of a clinical instrument for spectral diagnosis of cutaneous malignancy.

(Color online) (a), (b) Clinical instrument. (c) Fiber optic probe used with the clinical instrument.

Narasimhan Rajaram, et al. Appl Opt. ;49(2):142-152.
3.
Fig. 4

Fig. 4. From: Design and validation of a clinical instrument for spectral diagnosis of cutaneous malignancy.

(a) Diffuse reflectance spectrum (solid curve) and the corresponding LUT fit (circles) from a tissue phantom [μs′ (λ0) = 2.46 mm−1 and [Hb] = 2 mg/ml]. Scatter plot of the extracted versus expected values of (b) μa(λ) and (c) μs′ (λ) for all tissue phantoms. The solid line indicates perfect agreement.

Narasimhan Rajaram, et al. Appl Opt. ;49(2):142-152.
4.
Fig. 6

Fig. 6. From: Design and validation of a clinical instrument for spectral diagnosis of cutaneous malignancy.

In vivo measurements from normal skin (bold solid curve), dysplastic nevus (lighter solid curve) and malignant BCC (dashed curve) from three different patients. (a) Diffuse reflectance. The circles indicate the LUT model fit. (b) Intrinsic fluorescence spectra from 337 nm excitation. The circles indicate the fit to the linear combination model. (c) Intrinsic fluorescence spectra from 445 nm excitation.

Narasimhan Rajaram, et al. Appl Opt. ;49(2):142-152.
5.
Fig. 3

Fig. 3. From: Design and validation of a clinical instrument for spectral diagnosis of cutaneous malignancy.

(a) White light spectrum from the xenon flash lamp reflecting off a 20% reflectance standard. (b) Excitation pulses from the nitrogen laser at 337 nm and the dye laser at 445 nm. (c) Diffuse reflectance spectrum of a 1% intralipid solution. (d) Laser-induced fluorescence spectrum of a Rhodamine B solution (0.01 g/l).

Narasimhan Rajaram, et al. Appl Opt. ;49(2):142-152.
6.
Fig. 5

Fig. 5. From: Design and validation of a clinical instrument for spectral diagnosis of cutaneous malignancy.

(a) Data recorded from tissue phantoms with Stilbene 3 as fluorophore under test. The tissue phantoms contained a fixed scatterer concentration [μs′ (λ 0) = 1 mm−1] and varying concentrations of hemoglobin [0–2 mg/ml]. (b) Corresponding diffuse reflectance spectrum for each phantom. No measurement was possible for the intrinsic fluorescence phantom. (c) Intrinsic fluorescence spectra measured from a phantom (bold solid curve) and extracted by using the IFS model (dotted curve) compared with the laser-induced fluorescence spectrum (lighter solid curve).

Narasimhan Rajaram, et al. Appl Opt. ;49(2):142-152.

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