Results: 3

1.
FIG. 3.

FIG. 3. From: T Cell Responses of HIV-Infected Children after Administration of Inactivated or Live Attenuated Influenza Vaccines.

Comparison of ELISPOT decreases of LAIV and TIV recipients from baseline to week 4 after vaccination and from baseline to week 24 after vaccination. Data were derived from 85 and 90 HIV-infected TIV and LAIV recipients, respectively. Bars represent median differences from study week 0 to week 4 or 24. Asterisks (*) indicate significant differences between treatment groups. There were significantly larger differences in total and CD8 ELISPOT responses to all influenza strains in the seasonal vaccine of TIV vs. LAIV recipients (p ≤ 0.02).

Adriana Weinberg, et al. AIDS Res Hum Retroviruses. 2010 January;26(1):51-59.
2.
FIG. 2.

FIG. 2. From: T Cell Responses of HIV-Infected Children after Administration of Inactivated or Live Attenuated Influenza Vaccines.

ELISPOT responses of LAIV recipients. Data were derived from 90 HIV-infected recipients whose PBMCs were tested by ELISPOT after stimulation with PHA, influenza strains contained in the seasonal vaccine (A H3N2 Wyoming, A H1N1 New Caledonia and B Jilin), and mismatched influenza strains (A H3N2 Sydney and B Yamanashi). Bars represent medians for each group. Asterisks (*) indicate significant differences from baseline. (A) Total ELISPOT responses representing all PBMCs; (B) CD8 ELISPOT responses representing CD8 cells only. There were significant decreases in total ELISPOT responses against influenza strains A H3N2 Wyoming and B Jilin at 4 weeks after vaccination (p ≤ 0.03). All other total and CD8 ELISPOT responses were not significantly different from baseline.

Adriana Weinberg, et al. AIDS Res Hum Retroviruses. 2010 January;26(1):51-59.
3.
FIG. 1.

FIG. 1. From: T Cell Responses of HIV-Infected Children after Administration of Inactivated or Live Attenuated Influenza Vaccines.

ELISPOT responses of TIV recipients. Data were derived from 85 HIV-infected recipients whose PBMCs were tested by ELISPOT after stimulation with PHA, influenza strains contained in the seasonal vaccine (A H3N2 Wyoming, A H1N1 New Caledonia and B Jilin), and mismatched influenza strains (A H3N2 Sydney and B Yamanashi). Bars represent medians for each group. Asterisks (*) indicate significant differences from baseline and the unequal sign (≠) indicates significant difference from week 4. (A) Total ELISPOT responses representing all PBMCs; (B) CD8 ELISPOT responses representing CD8 cells only. There were significant decreases in total and CD8 ELISPOT responses against all influenza strains at 4 and 24 weeks after vaccination (p ≤ 0.03). There was a trend toward a decrease in PHA-stimulated ELISPOT at 4 weeks after vaccination (p = 0.06) followed by a significant rebound at 24 weeks (p = 0.01).

Adriana Weinberg, et al. AIDS Res Hum Retroviruses. 2010 January;26(1):51-59.

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