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1.
Figure 2

Figure 2. From: Comparison of Electron Spin Resonance Spectroscopy and Inductively-Coupled Plasma Optical Emission Spectroscopy for Biodistribution Analysis of Iron-Oxide Nanoparticles.

Advantage of the developed cryo-handling methodology for introduction of tissue samples into ESR tubes. (A,B) Pushing of the sample into the tube using glass rod under ambient temperature (A) leads to sample loss due to smearing of the tissue along the tube walls (B). (C.D) In contrast, cryogenically handled sample is pushed to the bottom of the tube without any tissue loss.

Beata Chertok, et al. Mol Pharm. ;7(2):375-385.
2.
Figure 4

Figure 4. From: Comparison of Electron Spin Resonance Spectroscopy and Inductively-Coupled Plasma Optical Emission Spectroscopy for Biodistribution Analysis of Iron-Oxide Nanoparticles.

Comparison of ICP-OES and ESR methodologies for MNP concentration analysis of (A) liver and (B) spleen obtained from rats which were administered with different concentrations of magnetic nanoparticles within the range of 12-25 mg Fe/kg. ICP-OES and ESR data sets show strong positive correlation with r = 0.97 and r = 0.94 for the liver and the spleen tissues, respectively.

Beata Chertok, et al. Mol Pharm. ;7(2):375-385.
3.
Figure 3

Figure 3. From: Comparison of Electron Spin Resonance Spectroscopy and Inductively-Coupled Plasma Optical Emission Spectroscopy for Biodistribution Analysis of Iron-Oxide Nanoparticles.

Representative ESR spectra of animal tissues excised from magnetically targeted animals (1) and animals not exposed to magnetic nanoparticles (2). Varied level of noise and different scale of the ordinate in spectra are primarily due to different receiver gain and modulation amplitude settings used in analyses (see Section 2.4).

Beata Chertok, et al. Mol Pharm. ;7(2):375-385.
4.
Figure 6

Figure 6. From: Comparison of Electron Spin Resonance Spectroscopy and Inductively-Coupled Plasma Optical Emission Spectroscopy for Biodistribution Analysis of Iron-Oxide Nanoparticles.

(A) ICP-OES and (B) ESR analysis of low MNP accumulating organs from animals administered with MNP under magnetic targeting (test) and animals not exposed to MNP (blank). Data of ICP-OES analysis are expressed as total iron concentration of the tissue. Data of ESR analysis are expressed as a double integral of acquired spectra normalized by the weight of tissue samples. Statistically significant difference in corresponding parameter between the nanoparticle-containing and blank organs is indicated by an asterix (*).

Beata Chertok, et al. Mol Pharm. ;7(2):375-385.
5.
Figure 5

Figure 5. From: Comparison of Electron Spin Resonance Spectroscopy and Inductively-Coupled Plasma Optical Emission Spectroscopy for Biodistribution Analysis of Iron-Oxide Nanoparticles.

(A) ICP-OES and (B) ESR analysis of high MNP accumulating organs from animals administered with MNP under magnetic targeting (test) and animals not exposed to MNP (blank). Data of ICP-OES analysis are expressed as total iron concentration of the tissue. Data of ESR analysis are expressed as a double integral of acquired spectra normalized by the weight of tissue samples. Statistically significant difference in corresponding parameter between the nanoparticle-containing and blank organs is indicated by an asterix (*).

Beata Chertok, et al. Mol Pharm. ;7(2):375-385.
6.
Figure 7

Figure 7. From: Comparison of Electron Spin Resonance Spectroscopy and Inductively-Coupled Plasma Optical Emission Spectroscopy for Biodistribution Analysis of Iron-Oxide Nanoparticles.

Biodistribution profiles of MNP in magnetically targeted animals obtained with (A) ICP-OES and (B) ESR methodologies. With ICP-EOS, plotted MNP concentrations (expressed in units of iron) were calculated from the data in Figures 5A and 6A by subtracting iron content of blank organs (background) from the iron content of MNP-exposed organs as described in Section 2.5. With ESR, plotted MNP values were calculated from the data in Figures 5B and 6B using a two-step analysis. First, weight-normalized double integral intensities of experimental tissues were corrected for the background values determined in tissues of non-MNP exposed animals. Then, background-corrected weight-normalized double integral values were recalculated for MNP concentrations using calibration curves with MNP standards as described in Section 2.4.

Beata Chertok, et al. Mol Pharm. ;7(2):375-385.
7.
Figure 1

Figure 1. From: Comparison of Electron Spin Resonance Spectroscopy and Inductively-Coupled Plasma Optical Emission Spectroscopy for Biodistribution Analysis of Iron-Oxide Nanoparticles.

A. Representative brain MRI images (Gradient Echo (GE) axial scans) of 9L-glioma bearing rats (1) not exposed to iron oxide nanoparticles (blank) and (2) administered with iron oxide nanoparticles under a gradient of magnetic flux density (red circles indicate location of tumor lesion). B. ICP-OES analysis of the corresponding excised tumor tissues revealing no statistical difference (p=0.383) in Fe concentration between tumors of (1) the blank and (2) the nanoparticle-administered rats.

Beata Chertok, et al. Mol Pharm. ;7(2):375-385.

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