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Results: 4

1.
Figure 3

Figure 3. From: A framework for analyzing both linkage and association: an analysis of Genetic Analysis Workshop 16 simulated data.

Different signals in different replicates. LDL SOLAR linkage results. While several regions exhibited LOD > 1 in multiple replicates, no region did so in all replicates.

E Warwick Daw, et al. BMC Proc. 2009;3(Suppl 7):S98-S98.
2.
Figure 1

Figure 1. From: A framework for analyzing both linkage and association: an analysis of Genetic Analysis Workshop 16 simulated data.

Associated SNPs account for linkage peaks. L-scores for MCMC oligogenic linkage analysis of LDL with (green) and without (red) simultaneous association testing at most causative SNPs. Including the causative SNPs reduces the linkage signal in most regions.

E Warwick Daw, et al. BMC Proc. 2009;3(Suppl 7):S98-S98.
3.
Figure 2

Figure 2. From: A framework for analyzing both linkage and association: an analysis of Genetic Analysis Workshop 16 simulated data.

Agreement between methods within replicate. Comparison of linkage results for simulated LDL at Visit 1, adjusted for age and sex, for L-scores from oligogenic simultaneous segregation and linkage analysis (without association testing) and for LOD from variance-components methods. Vertical scales are not comparable, but note agreement of peak locations

E Warwick Daw, et al. BMC Proc. 2009;3(Suppl 7):S98-S98.
4.
Figure 4

Figure 4. From: A framework for analyzing both linkage and association: an analysis of Genetic Analysis Workshop 16 simulated data.

Linkage and Association vs. gene locations. HDL Visit 1 adjusted for age and sex analyzed SOLAR and regression analyses in 2-cM wide windows (moving in 1-cM increments). In Replicate 1, no evidence for linkage was found. In Replicate 2, a LOD score > 2 at ~80 cM was found.

E Warwick Daw, et al. BMC Proc. 2009;3(Suppl 7):S98-S98.

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