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Figure 1

Figure 1. From: Dendritic tiling through TOR signalling.

TORC2 is essential for dendritic tiling by way of regulating Trc kinase activity. (AH) Schematics of dendritic tiling phenotypes in wild-type (A, E), trc–/– (B, F), ractor–/– (C, G), sin1–/– or rictor–/– (D, H). In wild-type, tiling occurs between sister neurites of the same neuron (iso-neuronal tiling, A) and between neurites of different neurons (hetero-neuronal tiling, E). Loss-of-function of trc or TORC2-specific components sin1 and rictor leads to significant overlaps between dendritic branches, representing defects in both iso- and hetero-neuronal tiling (B, D, F, H); however, TORC1-specific ractor mutant results in a significant reduction of dendritic branches with no tiling defects (C, G). (I) Model for the distinct functions of TORC1 and TORC2 in dendritic branching and tiling, respectively.

Weizhe Hong, et al. EMBO J. 2009 December 16;28(24):3783-3784.

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