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1.
Scheme 3

Scheme 3. From: Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single and Double Strand Breaks.

Formation of Interstrand cross-links used in this study.

Xiaohua Peng, et al. Biochemistry. ;49(1):11-19.
2.
Scheme 4

Scheme 4. From: Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single and Double Strand Breaks.

Repetitive incision of ICL containing radiolabeled “X” strand.

Xiaohua Peng, et al. Biochemistry. ;49(1):11-19.
3.
Scheme 2

Scheme 2. From: Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single and Double Strand Breaks.

Interstrand cross-link generation via synthetic precursor.

Xiaohua Peng, et al. Biochemistry. ;49(1):11-19.
4.
Scheme 5

Scheme 5. From: Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single and Double Strand Breaks.

Repetitive incision of ICL containing radiolabeled “Y” strand.

Xiaohua Peng, et al. Biochemistry. ;49(1):11-19.
5.
Scheme 1

Scheme 1. From: Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single and Double Strand Breaks.

Interstrand cross-link formation from 5-(2′-deoxyuridinyl)methyl radical (1).

Xiaohua Peng, et al. Biochemistry. ;49(1):11-19.
6.
Figure 3

Figure 3. From: Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single and Double Strand Breaks.

Histograms of UvrABC incision data for: A. 6, B. 7. Arrow length is proportional to relative amounts of incision within one strand.

Xiaohua Peng, et al. Biochemistry. ;49(1):11-19.
7.
Figure 4

Figure 4. From: Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single and Double Strand Breaks.

Identification of UvrABC incision product from 6 on unlabeled strand. A. Independently synthesized postulated products. B. Denaturing PAGE analysis of incision product and independently synthesized standards.

Xiaohua Peng, et al. Biochemistry. ;49(1):11-19.
8.
Figure 5

Figure 5. From: Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single and Double Strand Breaks.

Time course of UvrABC incision of 32P-6 in which A. 5′-terminus of “X” strand is labeled and B. 5′-terminus of “Y” strand is labeled. 32P-Labeled terminus is indicated by *. Note: Cartoons of products resulting from incision on the unlabeled strand are shown.

Xiaohua Peng, et al. Biochemistry. ;49(1):11-19.
9.
Figure 6

Figure 6. From: Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single and Double Strand Breaks.

Time course of UvrABC incision of 32P-7 in which “ A. 5′-terminus of “Y” strand is labeled and B. 5′-terminus of “X” strand is labeled. 32P-Labeled terminus is indicated by *. Note: Cartoons of products resulting from incision on the unlabeled strand are shown.

Xiaohua Peng, et al. Biochemistry. ;49(1):11-19.
10.
Figure 2

Figure 2. From: Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single and Double Strand Breaks.

UvrABC incision of 7. A. Strand containing modified thymidine labeled at its 3′-terminus (3′-32P-“X”-strand) B. Strand containing cross-linked dA labeled at its 3′-terminus (3′-32P-“Y”-strand) C. Strand containing modified thymidine labeled at its 5′-terminus (5′-32P-“X”-strand) D. Strand containing cross-linked dA labeled at its 5′-terminus (5′-32P-“Y”-strand); A + G, sequencing reaction. The cartoons identify the products produced from incision of the unlabeled strand. * indicates position of 32P-label.

Xiaohua Peng, et al. Biochemistry. ;49(1):11-19.
11.
Figure 1

Figure 1. From: Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single and Double Strand Breaks.

UvrABC incision of 6. A. Strand containing modified thymidine labeled at its 3′-terminus (3′-32P-“X”-strand) B. Strand containing cross-linked dA labeled at its 3′-terminus (3′-32P-“Y”-strand) C. Strand containing modified thymidine labeled at its 5′-terminus (5′-32P-“X”-strand) D. Strand containing cross-linked dA labeled at its 5′-terminus (5′-32P-“Y”-strand); A + G, sequencing reaction. The cartoons identify the products produced from incision of the unlabeled strand. * indicates position of 32P-label.

Xiaohua Peng, et al. Biochemistry. ;49(1):11-19.
12.
Figure 7

Figure 7. From: Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single and Double Strand Breaks.

Native PAGE analysis of UvrABC incision of 7. A. Strand containing modified thymidine labeled at its 3′-terminus (3′-32P-“X” strand); B. Strand containing cross-linked dA labeled at its 3′-terminus (3′-32P-“Y” strand). Compound 5 is used as a single stranded 50 nt marker. 3′-32P-11 (A) and 3′-32P-12 (B) are used as double strand cleavage markers. C. Sequences of 11 and 12.

Xiaohua Peng, et al. Biochemistry. ;49(1):11-19.

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