We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 4

2.
Figure 1

Figure 1. Effects of mid- (MEX) and high- (HEX) level exercise on body weight in G93A transgenic mice. From: Moderate exercise delays the motor performance decline in a transgenic model of ALS.

G93A mice exposed to either MEX or HEX exercise maintained a 5-8% lower body weight compared to sedentary (SED) G93A transgenic mice. All values are mean ±SEM.

Isabel Carreras, et al. Brain Res. ;1313:192-201.
3.
Figure 3

Figure 3. Quantification of motor neuron number in the ventral horn of cervical, thoracic and lumbar cord sections using an Optical Fractionator probe in the StereoInvestigator software. From: Moderate exercise delays the motor performance decline in a transgenic model of ALS.

A. Area of interest was traced at x4 magnification. B. The counting frame size used was 75×75 (mm) and the counting frame area was (XY)= 5625 mm2. C. Cell counting was done with a x60 N.A 1.4 oil objective. Neurons were counted only if their diameter was 15 mm or larger and only if the neuron nucleolus was inside the counting frame and the neuron was not touching the excluding borders.

Isabel Carreras, et al. Brain Res. ;1313:192-201.
4.
Figure 2

Figure 2. Effects of mid- (MEX) and high- (HEX) level exercise on rotarod performance in G93A transgenic mice compared to sedentary (SED) G93A transgenic mice. From: Moderate exercise delays the motor performance decline in a transgenic model of ALS.

A. Starting at 30 days of age mice were placed, twice a week, on a rod at 12 rpm for 60 secs and the time remaining on the rod before falling was recorded. Not shown in the figure is the rotarod performance from 30 to 70 days of age, which was for all mice at maximum (60 s). All values are mean ±SEM. Statistical analysis was performed by ANOVA followed by post-hoc test (Tukey-Kramer), p<0.05 is considered significant. Significance (*) was reached for MEX vs. SED and HEX at 105 days of age. B. Demonstration of fitting the total data to a logistic function that combined the onset and slope of the decline. We used the R-factor ratio test, which is quite similar to an F-test to compare the fits for each set of parameters with the R-factor ratio determining the significance of the fits.

Isabel Carreras, et al. Brain Res. ;1313:192-201.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk