Results: 4

1.
Fig. 3.

Fig. 3. From: Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium.

Site-specific changes in gene expression induced by smoking. A: heat map of 27 genes differentially expressed as a result of smoking more dramatically in bronchial epithelium. B: CCL28 is differentially expressed between smokers and nonsmokers in nose, but not in bronchus. C: DNER is upregulated by smoking in bronchus but is downregulated in nose.

Xiaoling Zhang, et al. Physiol Genomics. 2010 March;41(1):1-8.
2.
Fig. 2.

Fig. 2. From: Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium.

A: similarity between bronchial and nasal gene expression. Gene expression estimates for the 119 genes (see Supplemental Table S4) that vary between smokers and nonsmokers were z-score normalized within each tissue and organized using hierarchical clustering (green indicates lower than average expression, red indicates higher than average expression). B: real-time PCR validation of select genes (colored pink in A) in 3 smokers and 3 nonsmokers. The y-axis represents relative log2 expression. Error bars indicate SE. Differences in expression were evaluated using Student's t-test.

Xiaoling Zhang, et al. Physiol Genomics. 2010 March;41(1):1-8.
3.
Fig. 4.

Fig. 4. From: Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium.

In silico validation of genes more dramatically altered by smoking in bronchus (see Fig. 3A), using an independent U133A data. Among 27 genes, 17 genes with corresponding U133A probe sets were identified. A: heat map of the expression profiles of these 17 genes in previously published U133A datasets consisting of bronchial and nasal samples from current and never smokers. B: principal component analysis (PCA) of 17 genes in U133A bronchus and nose data. Each point represents a subject (red: smokers, blue: nonsmokers).

Xiaoling Zhang, et al. Physiol Genomics. 2010 March;41(1):1-8.
4.
Fig. 1.

Fig. 1. From: Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium.

Methodology for identifying genes that are commonly and site-specifically differentially expressed in response to tobacco smoke exposure. For each gene, the relationship between gene expression in log2 scale, site, status, and the interaction between site and status was examined with a mixed linear regression model. |fd| B represents the absolute log2 magnitude of the difference between current and never smoker in bronchial samples (fdB = βstatus), and fdN is the magnitude of the difference in nasal samples (fdN = βstatus +βnose.status). FDR, false discovery rate.

Xiaoling Zhang, et al. Physiol Genomics. 2010 March;41(1):1-8.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk