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1.
Figure 2

Figure 2. From: Recent Advances in the Pathogenesis of Syndromic Autisms.

Potential pathogenetic mechanisms of syndromic autism. Several medical conditions associated with syndromic autism appear to influence and potentially disrupt neurodevelopmental processes, including brain growth, cortical connectivity, and neurotransmitters pathways. These neurobiological alterations likely affect the developmental trajectory of social behavior and communication during early stages of childhood and determine the different clinical phenotypes of ASD.

A. Benvenuto, et al. Int J Pediatr. 2009;2009:198736.
2.
Figure 1

Figure 1. From: Recent Advances in the Pathogenesis of Syndromic Autisms.

Genetic and epigenetic factors involved in the pathogenesis of autism. Interactions between multiple genes and environmental factors, such as intrauterine infections, alcohol/toxins exposure, and obstetrical suboptimality, can influence intrauterine and early postnatal brain development and disrupt crucial neurobiological pathways, from neuronal migration and cortical organization to synaptic and dendritic conformation, resulting in alterations of neurobehavioral trajectories that are involved in the pathogenesis of ASD.

A. Benvenuto, et al. Int J Pediatr. 2009;2009:198736.

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