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Results: 4

1.
Figure 1

Figure 1. From: Effect of aging on cellular mechanotransduction.

A simplified schematic of the mechanotransduction processes. The mechanotransductive responses consist of three distinct phases: signal transduction, signal propagation, and cellular response.

Miaozong Wu, et al. Ageing Res Rev. ;10(1):1-15.
2.
Figure 3

Figure 3. From: Effect of aging on cellular mechanotransduction.

Stress-induced signaling in aorta. A. Effect of aging on load-induced signaling following multi-axial stress in the aging F344BN aorta. B. Effect of aging on load-induced signaling following uni-axial stress in the aging F344BN aorta. Unfilled circles represent age-related differences (see text for details).

Miaozong Wu, et al. Ageing Res Rev. ;10(1):1-15.
3.
Figure 4

Figure 4. From: Effect of aging on cellular mechanotransduction.

An overview of the relationship between insulin/IGF-I desensitization and Alzheimer s disease. Insulin resistance is associated with diminished activation of Shc/GRB2/MAPK and IRS/PI3K/Akt signaling, which could lead to increased Tau phosphorylation and Aβ accumulation (see text for details).

Miaozong Wu, et al. Ageing Res Rev. ;10(1):1-15.
4.
Figure 2

Figure 2. From: Effect of aging on cellular mechanotransduction.

Dysregulation of mechanotransduction in aging skeletal muscle. At rest the basal expression of mechano growth factor (MGF or IGF-IEc) and IGF-I receptor (IGF-IR) are decreased, while myostatin expression is increased. With aging, the basal phosphorylation of MAPK, Akt and p70S6k are higher, while Akt activity may be decreased. These alterations are thought to impair the ability of aged skeletal muscle to sense and respond to the mechanical stimuli, which may be associated with decreases in mechanically-induced hypertrophy. ActRIIb: activin receptor IIb.

Miaozong Wu, et al. Ageing Res Rev. ;10(1):1-15.

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