Results: 4

1.
Figure 1

Figure 1. From: NORMAL REGIONAL LYMPH NODE ENRICHMENT OF ANTIGEN-SPECIFIC REGULATORY T CELLS WITH AUTOIMMUNE DISEASE-SUPPRESSIVE CAPACITY.

Treg from normal ovarian LN suppress AOD more efficiently than Treg from non-ovarian LN. (A and B): Severity of AOD in d3tx recipients of ovarian LN Treg (A) or non-ovarian LN Treg (B). Filled circles represent positive serum oocyte antibody. (C): AOD incidences between recipients of ovarian LN Treg (squares) and recipients of non-ovarian LN Treg (circles) (n = 6-8).

Karen M. Wheeler, et al. J Immunol. ;183(12):7635-7638.
2.
Figure 2

Figure 2. From: NORMAL REGIONAL LYMPH NODE ENRICHMENT OF ANTIGEN-SPECIFIC REGULATORY T CELLS WITH AUTOIMMUNE DISEASE-SUPPRESSIVE CAPACITY.

Selective enrichment of EAP-specific Treg and DA-specific Treg in prostate LN and lacrimal gland LN of normal mice. (A and B): EAP severity between d3tx recipients of Treg from prostate LN (A) and lacrimal gland LN (B). Incidences of EAP between these Treg recipients are shown in C (squares, prostate LN Treg recipients; circles, lacrimal gland LN Treg recipients). (D and E): DA severity between d3tx recipients of Treg from prostate LN (D) and lacrimal gland LN (E). (F): Incidence of DA between these Treg recipients (squares, prostate LN Treg recipients; circles: lacrimal gland LN Treg recipients). Filled circles denote positive prostate autoantibody.

Karen M. Wheeler, et al. J Immunol. ;183(12):7635-7638.
3.
Figure 3

Figure 3. From: NORMAL REGIONAL LYMPH NODE ENRICHMENT OF ANTIGEN-SPECIFIC REGULATORY T CELLS WITH AUTOIMMUNE DISEASE-SUPPRESSIVE CAPACITY.

Loss and gain in prostate Ag expression influences EAP-specific Treg activity in the normal prostate LN. (A): EAP severity and incidence in mice that received Treg (0.03 – 0.05×106) from prostate LN (PDLN) or lacrimal gland LN (LGLN), obtained from: normal donors, NOX donors, or donors with NOX and DHT treatment (NOX+DHT). (B): Immunohistochemical detection of prostate antigens in normal mice, NOX mice, and NOX+DHT. P-values determined by Mann-Whitney test.

Karen M. Wheeler, et al. J Immunol. ;183(12):7635-7638.
4.
Figure 4

Figure 4. From: NORMAL REGIONAL LYMPH NODE ENRICHMENT OF ANTIGEN-SPECIFIC REGULATORY T CELLS WITH AUTOIMMUNE DISEASE-SUPPRESSIVE CAPACITY.

Organ distribution of tissue inflammation in B6 RAG-/- recipients of CD4+CD25- T cells from individual LN of wild type B6 donors. Data represent the incidence (%) and severity (mean ± SD) of tissue inflammation and destruction. Comparisons are made between pathology induced by lacrimal gland-draining cervical LN (CLN; gray bars), mesenteric LN (MLN; white bars) or prostate LN (PLN; black bars). Each recipient received 0.2×106 CD4+CD25- T cells i.v., and was studied 3-4 weeks later. Data represents the summation of three independent experiments, with two mice per experiment. LB, large bowel; LG, lacrimal gland; SB, small bowel.

Karen M. Wheeler, et al. J Immunol. ;183(12):7635-7638.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk