Results: 4

1.
Figure 3

Figure 3. From: Neonatal intra-hippocampal immune challenge alters dopamine modulation of prefrontal cortical interneurons in adult rats.

PPI was disrupted in LPS-treated adult rats. Bar graph illustrating percent PPI with three prepulse intensities in sham (light) and LPS (dark) rats. Treatment status: F(1,82)=5.09; p=0.03. PPI level: F(2,82) = 3.202; p=0.055. No interaction: F(2,82) = 0.131; p=0.878.

Carlos Feleder, et al. Biol Psychiatry. ;67(4):386-392.
2.
Figure 4

Figure 4. From: Neonatal intra-hippocampal immune challenge alters dopamine modulation of prefrontal cortical interneurons in adult rats.

D2 effects on interneurons. A. Increase in excitability by the D2 agonist quinpirole in fast-spiking interneurons recorded in PFC slices from sham rats (***p<0.001). B. Lack of effect in slices from LPS treated rats. C. Graph showing normalized responses to quinpirole in both groups, revealing a 30% increase in excitability in sham rats but no change in LPS treated rats. A third group from naïve rats showing a 30% increase in excitability is also shown. D, E. Representative traces illustrating the effect of quinpirole in a slice from a sham rat (D) and in a slice from an LPS treated rat (E).

Carlos Feleder, et al. Biol Psychiatry. ;67(4):386-392.
3.
Figure 1

Figure 1. From: Neonatal intra-hippocampal immune challenge alters dopamine modulation of prefrontal cortical interneurons in adult rats.

Injection of LPS did not cause damage to the dorsal or ventral hippocampus. A, B. Rostral (top row) and caudal (bottom row) views of the ventral hippocampus in representative LPS injected (A) and sham operated (B) rats indicate that LPS did not alter the morphology of the hippocampus or surrounding brain regions. C, D. Higher magnification of the squares indicated in A for a representative LPS-treated rat. E, F. Higher magnification of the squares indicated in B. The pyramidal layer in these sections is intact, and the areas represented are those typically damaged in the NVHL model.

Carlos Feleder, et al. Biol Psychiatry. ;67(4):386-392.
4.
Figure 2

Figure 2. From: Neonatal intra-hippocampal immune challenge alters dopamine modulation of prefrontal cortical interneurons in adult rats.

Effect of LPS treatment on TNF, IL-1 and IL-2 protein levels in the PFC, NA and hippocampus, measured by ELISA. A. Interleukin levels 48 hours after the LPS injection. Open bars: vehicle injected rats; black bars: LPS-treated rats. B. Similar measures two weeks following the LPS injection. C. Cytokine levels in adult brains. All data in this and subsequent figures are mean ± SD. *p<0.05; Tukey multiple comparison test following a significant two-way ANOVA.

Carlos Feleder, et al. Biol Psychiatry. ;67(4):386-392.

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