Results: 3

1.
Figure 2

Figure 2. From: The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology.

Schematic of sirtuin targets that are proposed to be operational in the modulation of mitochondrial function in the cardiovascular system. Note the SIRT5 target carbamoyl phosphate synthetase 1 is not shown in this schematic as the detoxification of ammonia is not thought to be operational in the cardiovascular system. A single sided arrow indicates a functional interaction. A double sided arrows represents a protein:protein interaction.

Zhongping Lu, et al. Circ Res. ;105(9):830-841.
2.
Figure 1

Figure 1. From: The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology.

Biochemistry of NAD biosynthesis and sirtuin activity. The de novo pathway is the minor pathway and the salvage pathway the major pathway. The solid lines depict the biochemical pathways. The white boxes with their hatched lines represent biochemical and physiologic mediators of the NAD biosynthesis and sirtuin activation pathways. The black box shows the consequences of sirtuin mediated deacetylation. The hatched box represents a hypothetical modification that has not been robustly characterized. Abbreviations: NaMN – nicotinic acid mononucleotide; NMN – nicotinamide mononucleotide; NAMPT – nicotinamide phosphoribosyltransferase; NMNAT – nicotinamide/nicotinic acid mononucleotide adenyltransferase.

Zhongping Lu, et al. Circ Res. ;105(9):830-841.
3.
Figure 3

Figure 3. From: The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology.

Potential role of sirtuin mediated modulation of mitochondrial biology in the cardiovascular system. The direct and indirect effects of mitochondrial function that have been characterized are shown under the heart and vascular pathways columns. The potential effects of mitochondrial metabolic protein modifications are shown in the column to the right. How these may effect fuel substrate use and selection and the adaptations to direct cardiac stressors and to metabolic stresses on the heart and vasculature have yet to be ascertained. The speculative functions of acetyl-lysine PTM's is highlighted by their grey background.

Zhongping Lu, et al. Circ Res. ;105(9):830-841.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk