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Results: 4

1.
Fig. 1

Fig. 1. From: Dissociation between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats in baseline performance and methylphenidate response on measures of attention, impulsivity and hyperactivity in a Visual Stimulus Position Discrimination Task.

Timeline of experiment. The duration of the food and task training including the days when animals’ baseline performance was recorded are shown on the upper panel. The duration of the treatment phases for the low, medium and high doses are shown on the lower panel.

Panayotis K. Thanos, et al. Pharmacol Biochem Behav. ;94(3):374-379.
2.
Fig. 3

Fig. 3. From: Dissociation between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats in baseline performance and methylphenidate response on measures of attention, impulsivity and hyperactivity in a Visual Stimulus Position Discrimination Task.

WKY and SHR correct lever presses in different light cue conditions with different treatments. The four dose treatments (vehicle, 2 mg/kg, 5 mg/kg, 10 mg/kg) are shown on the X axis and the percent correct responses are shown on the Y axis. The line graphs represent the correct lever presses during the three light cues (100 ms, 300 ms, 1 s) for SHR (3.1) and WKY (3.2) rats. MP treatments with 5 mg/kg and 10 mg/kg produced pronounced choice accuracy deficits at all stimulus duration for the WKY rats (lower panel) but only mild impairment for the SHR rats (top panel).
* Annotates significant change from performance in vehicle condition

Panayotis K. Thanos, et al. Pharmacol Biochem Behav. ;94(3):374-379.
3.
Fig. 4

Fig. 4. From: Dissociation between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats in baseline performance and methylphenidate response on measures of attention, impulsivity and hyperactivity in a Visual Stimulus Position Discrimination Task.

Behavioral measures for WKY and SHR with different treatments. 4.1. Response omissions. The four dose treatments (vehicle, 2 mg/kg, 5 mg/kg, 10,g/kg) are shown on the X axis. The percent omissions are shown on the Y axis. MP treatments with 5 mg/kg and 10 mg/kg produced marked increase in response omissions for the WKY rats but not for the SHR rats. Due to the fact that the omission curves for each strain were very similar across light cue conditions, the four treatments were collapsed in a single line graph for each strain. 4.2. ITI responses. The four dose treatments (vehicle, 2 mg/kg, 5 mg/kg, 10 mg/kg) are shown on the X axis. The ITI responses are shown on the Y axis. The MP treatments with 5 mg/kg and 10 mg/kg produced significant decreases in non-reinforced ITI responses for the WKY rats and non-significant increase for the SHR rats. 4.3. Locomotor activity. The four dose treatments (vehicle, 2 mg/kg, 5 mg/kg, 10,g/kg of MP) are shown on the X axis. The locomotion measures are shown on the Y axis. MP treatments magnified the baseline activity difference between the two stains represented by the line graphs for the WKY and the SHR rats.
* Annotates significant change from performance in vehicle condition
** Annotates significant difference between locomotor activity between WKY and SHR vehicle condition

Panayotis K. Thanos, et al. Pharmacol Biochem Behav. ;94(3):374-379.
4.
Fig. 2

Fig. 2. From: Dissociation between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats in baseline performance and methylphenidate response on measures of attention, impulsivity and hyperactivity in a Visual Stimulus Position Discrimination Task.

(2.1)WKY and SHR performance in different light cue conditions during the vehicle treatment. The three light cues (100 ms, 300 ms, 1 s) are shown on the X axis and the percent correct responses are shown on the Y axis. The two line graphs represent the choice accuracy for SHR and WKY rats as a function of stimulus cue duration. No difference was evident between the groups in the baseline condition. (2.2) Within-session data comparing SHR and WKY rats at the 100 ms signal for the saline treatment session prior to drug treatment. A slight warm-up effect and end-of-session drop off effect is revealed, but no differential accuracy between the two groups at the final session blocks, as might be predicted if the two groups differed in vigilance or fatigue.

Panayotis K. Thanos, et al. Pharmacol Biochem Behav. ;94(3):374-379.

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