Results: 4

1.
Fig 1.

Fig 1. From: Myeloperoxidase Genotypes and Enhanced Efficacy of Chemotherapy for Early-Stage Breast Cancer in SWOG-8897.

Schema of trial design for Southwest Oncology Group SWOG-8897 and tissues available for genotyping. CMF, cyclophosphamide, methotrexate, and fluorouracil; CAF, cyclophosphamide, doxorubicin, and fluorouracil; TAM, tamoxifen.

Christine B. Ambrosone, et al. J Clin Oncol. 2009 October 20;27(30):4973-4979.
2.
Fig 4.

Fig 4. From: Myeloperoxidase Genotypes and Enhanced Efficacy of Chemotherapy for Early-Stage Breast Cancer in SWOG-8897.

Potential mechanisms of action for associations between myeloperoxidase (MPO) genotypes and disease-free survival through (A) effects of cyclophosphamide (CPA) and (B) interactions with tamoxifen. ER, estrogen receptor.

Christine B. Ambrosone, et al. J Clin Oncol. 2009 October 20;27(30):4973-4979.
3.
Fig 2.

Fig 2. From: Myeloperoxidase Genotypes and Enhanced Efficacy of Chemotherapy for Early-Stage Breast Cancer in SWOG-8897.

Disease-free survival by myeloperoxidase (MPO) genotypes among women who (A) received adjuvant therapy, (B) did not receive adjuvant therapy, (C) received adjuvant cyclophosphamide-containing chemotherapy with further assignment to tamoxifen, and (D) received adjuvant cyclophosphamide-containing chemotherapy and no tamoxifen therapy. S8897, Southwest Oncology Group SWOG-8897 trial. Key in (A) also applies to parts (B), (C), and (D).

Christine B. Ambrosone, et al. J Clin Oncol. 2009 October 20;27(30):4973-4979.
4.
Fig 3.

Fig 3. From: Myeloperoxidase Genotypes and Enhanced Efficacy of Chemotherapy for Early-Stage Breast Cancer in SWOG-8897.

Myeloperoxidase (MPO) immunostaining in breast cancer tissues. Sections from paraffin-embedded ductal carcinoma tissues were immunostained with polyclonal antibodies against human MPO. MPO protein is detected in invading macrophages and neutrophils (A-C, ×20) and in dead cells and detritus in the lumen of ducts (D, F, G, H), as well as in (E) macrophages associated with adjacent adipose cells.

Christine B. Ambrosone, et al. J Clin Oncol. 2009 October 20;27(30):4973-4979.

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