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Results: 2

1.
Fig 1

Fig 1. Amino acid sequences of the HBV core protein (aa 1-150). From: CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low levels of HBV DNA.

Sequences of HBV core protein of patients aligned with the genotype A sequence pHBV3200 21. The grouping of the shaded sequences corresponds to strains with different BCP mutants previously published. 17

Hossein Sendi, et al. J Clin Virol. ;46(3):259-264.
2.
Fig 2

Fig 2. Appearance of major CTL and B epitopes, the most variable regions, and “hot spot” aa exchanges on the surface of the HBc tetramer. From: CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low levels of HBV DNA.

3D data are presented from the X-ray structure of the HBc, genotype A 3 by Chimera software.20 Chains A, B, C, and D of the HBc tetramer are colored pink, light green, gold, and light blue, respectively; three different viewing angles are used for HBc drawings: (i) A and B, (ii) C, D, and E, and (iii) F. A, CTL epitope 18-FLPSDFFPSV-27 is colored red, the “hot spot” S21 is blue; B, the same as A, but the B epitope 74-NNLEDPASRDLVVNYV-89 (red) and the “hot spot” A80 (blue) are added; C, two most variable regions 64-ELMTLAT-70 and 91-TNMGL-95 are colored blue, E64 — black, and M93 — red; D, the same as C, but the S87 is colored red; E, the same as C, but the T67 is red; F — the inner part of the HBc tetramer is exposed, “hot spots” of the inner HBc surface Y38 and S49 are red, A80 is colored red to mark the tips of the HBc spikes in the new presentation angle.

Hossein Sendi, et al. J Clin Virol. ;46(3):259-264.

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