Results: 2

1.
Figure 1

Figure 1. From: Glucocorticoid Efficacy in Asthma: Is Improved Tissue Remodeling Upstream of Anti-Inflammation.

Binding and activation of the glucocorticoid receptor. Circulating steroids diffuse across cell membranes and bind inactive GRs in the cytosol. The heat shock proteins (HSP) bound to the unoccupied GR receptor are displaced by the steroid ligand. The steroid-receptor complex then translocates to the nucleus where ligand-activated GR dimers are shown binding to sRE cis-elements. This activates sRE containing genes leading to transactivation or transrepression.

Robert J. Freishtat, et al. J Investig Med. ;58(1):19-22.
2.
Figure 2

Figure 2. From: Glucocorticoid Efficacy in Asthma: Is Improved Tissue Remodeling Upstream of Anti-Inflammation.

Model of cell cycle progression in normal respiratory epithelium. In normal tissue, circadian peaks in endogenous GC’s act via the GC receptor (GR) (1) to induce expression of Period (Per) genes (2). Increased Per expression negatively feeds back to decrease Clock-Bmal1 dimerization (3) resulting in results in a pause of the cell cycle at the G1 phase. Ultimately, less Clock-Bmal1 leads to less Per allowing the cell cycle to progress.

Robert J. Freishtat, et al. J Investig Med. ;58(1):19-22.

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