Display Settings:

Items per page
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 10

1.
Figure 5

Figure 5. From: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.

Structure of the predominant mannosyl-β-1-phosphomycoketides from M. tuberculosis H37Rv.

Devinder Kaur, et al. Adv Appl Microbiol. ;69:23-78.
2.
Figure 6

Figure 6. From: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.

Proposed pathway for the biosynthesis of mycobacterial arabinogalactan.
AG synthesis is initiated by a transfer of GlcNAc-1-phosphate onto a polyprenyl-phosphate and continues with the sequential addition of glycosyl residues to this lipid carrier. The enzymes that have been proposed to be involved in this process are indicated on the figure.

Devinder Kaur, et al. Adv Appl Microbiol. ;69:23-78.
3.

Figure 2. From: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.

Biogenesis of PIM, LM and LAM.
A) Schematic representation of the current understanding of the PIM, LM and LAM biosynthetic pathways in M. tuberculosis. B) Three-dimensional structure of a PimA-GDP-Man complex. Cartoon representation of the monomeric form of PimA from M. smegmatis. The structure is “color-ramped” from the N-terminus (NTD) (blue) to the C-terminus (CTD) (red).

Devinder Kaur, et al. Adv Appl Microbiol. ;69:23-78.
4.
Figure 8

Figure 8. From: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.

Structure of a representative monomer of mycobacterial PG prior to peptide trimming. R1, N-glycolylmuramic acid residue of another monomer; R2, N-acetylglucosamine residue of another monomer; R3, H or the linker unit of AG; R4, H, COCH3 (N-acetyl) or COCH2OH (N-glycolyl); R5, R6, R8, OH, NH2 or OCH3; R7, H, or cross-linked to penultimate d-Ala or to the d-center of another meso-DAP residue.

Devinder Kaur, et al. Adv Appl Microbiol. ;69:23-78.
5.
Figure 10

Figure 10. From: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.

Mycothiol.
A) Structure of mycothiol; B) Three-dimensional structure of a CgMshA-UDP-Ins-P complex. Cartoon representation of the dimeric form of CgMshA. One monomer is “color-ramped” from the N-terminus (blue) to the C-terminus (red). The second monomer is in grey and the UDP and Ins-P substrates are shown in yellow. The dimer interface is entirely composed of residues from the N-terminal domain.

Devinder Kaur, et al. Adv Appl Microbiol. ;69:23-78.
6.
Figure 4

Figure 4. From: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.

Structures of phenolic glycolipids and p-hydroxybenzoic acid derivatives from M. tuberculosis.
The lipid core of PGL from M. tuberculosis is composed of phenolphthiocerol esterified by mycocerosic acids (m = 15-17; n = 20-22, n’, n” = 16, 18; p, p’ = 2-5; R = -CH2-CH3 or –CH3). The trisaccharide substituent of PGL and p-HBAD-II consists of 2,3,4-tri-O-methyl-α-L-Fucp-(1→3)-α–L-Rhap-(1→3)-2-O-methyl-α-L-Rhap. The monosaccharide substituent found in p-HBAD-I consists of 2-O-methyl-α-L-Rhap.

Devinder Kaur, et al. Adv Appl Microbiol. ;69:23-78.
7.
Figure 7

Figure 7. From: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.

A schematic representation of the M. tuberculosis H37Rv cell wall biosynthetic gene cluster (Rv3779-Rv3809c) encompassing genes involved (or likely to be) in the biosynthesis of mycolic acids (accD4, pks13, fadD32, fbpD, fbpA), arabinogalactan (glfT1, Rv3790, Rv3791, atfA, embA, embB, atfB, ubiA, glfT2, glf), and LAM (embA, embB, embC, atfB,, ubiA). Genes annotated or suggested as glycosyltransferases are marked in bold.

Devinder Kaur, et al. Adv Appl Microbiol. ;69:23-78.
8.
Figure 3

Figure 3. From: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.

Structures of some trehalose-derived molecules from Mycobacterium tuberculosis.
The major sulfolipid SL-I (2,3,6,6′-tetraacyl α-α’-trehalose-2′-sulfate) is represented. In SL-I, trehalose is sulfated at the 2′ position and esterified with palmitic acid and the multimethyl-branched phthioceranic and hydroxyphthioceranic acids. In DAT (2,3-di-O-acyltrehalose), trehalose is esterified with stearic acid and the multimethyl-branched mycosanoic acid. In PAT (polyacyltrehalose), trehalose is esterified with stearic acid and the multimethyl-branched mycolipenic acids. In TMM and TDM, trehalose is esterified with mycolic acids. The oligosaccharide of the LOS of M. tuberculosis Canetti strains consists of 2-O-methyl-α-L-Fucp-(1→3)-β–D-Glcp-(1→3)-2-O-methyl-α-L-Rhap-(1→3)-2-O-methyl-α-L-Rhap-(1→3)-β-D-Glcp-(1→3)-4-O-methyl-α-L-Rhap-(1→3)-6-O-methyl-α-D-Glc-(1→1)-α-D-Glc. R are 2,4-dimethylhexadecanoic acid and 2,4,6,8-tetramethyloctadecanoic acid residues.

Devinder Kaur, et al. Adv Appl Microbiol. ;69:23-78.
9.
Figure 1

Figure 1. From: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.

A current perspective of the cell envelope of Mycobacterium tuberculosis.
Represented is a theoretical model of the outer membrane (OM) wherein similar extractable lipids are present in both leaflets and the meromycolates of bound mycolic acids span the entire hydrophobic region. Another model proposes the meromycolate chains to be folded upon themselves to create a more compact structure, compatible with the observed thickness of the OM (see text for details). The capsular material is not represented here. Extractable lipids represented in the outer membrane include PIMs and acyltrehaloses whereas those of the plasma membrane include phospholipids and PIMs. PM, plasma membrane; PG, peptidoglycan; AG, arabinogalactan; OM, outer membrane. The Galf and Araf residues of AG are represented in blue and red, respectively. The succinyl and galactosamine residues of AG are in green. Manp residues in PIM, LM and LAM are in red; Araf residues are purple.

Devinder Kaur, et al. Adv Appl Microbiol. ;69:23-78.
10.
Figure 9

Figure 9. From: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.

Methylglucose lipolysaccharides.
A) Structure of the MGLPs from M. bovis BCG. The non-reducing end of the polymer is acylated by a combination of acetate, propionate and isobutyrate (R’), whereas octanoate (R) esterifies the position 1 of glyceric acid and zero to three succinate groups (R”) esterify the Glc residues of the reducing end. MGLPs occur as a mixture of four main components that differ in their content of esterified succinic acid. B) Three-dimensional structure of the glucosyl-3-phosphoglycerate synthase from M. avium subsp. paratuberculosis (MAP2569c) in complex with UDP-Glc. Cartoon representation of the dimeric form of the MAP2569c. One monomer is “color-ramped” from the N-terminus (blue) to the C-terminus (red). The second monomer is in grey and UDP-Glc is shown in yellow.

Devinder Kaur, et al. Adv Appl Microbiol. ;69:23-78.

Display Settings:

Items per page

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk