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Figure 2

Figure 2. From: The transcriptional regulation of the human CYP2C genes.

Interactions between nuclear receptors and coactivators precisely modulate the transcription of CYP2C9. The coactivator NcoA6 bridges the HNF4α binding site(s) within the basal promoter and the proximal CAR/PXR-RE site by interacting with HNF4α and CAR, producing a synergistic transactivation of the CYP2C9 promoter. The coactivators PGC-1α and SRC-1 also interact with HNF4α, and probably also with GR, to regulate the activity of the CYP2C9 promoter.

Yuping Chen, et al. Curr Drug Metab. ;10(6):567-578.
Figure 1

Figure 1. From: The transcriptional regulation of the human CYP2C genes.

Summary of the known response elements for nuclear receptors regulating the CYP2C8, 2C9, and 2C19 genes. This figure summarizes our current view of the regulatory elements within the three human CYP2C gene promoters. The hexamer sequences are shown in capital letters for each element along with their exact locations within each promoter. The arrows indicate the direct repeat of each element. The elements which bind nuclear receptors in vitro but are identified as nonfunctional by mutagenesis in luciferase promoter studies are shown with grey lines. Newly identified HNF4α sites in CYP2C9 and CYP2C8 are indicated with dark parallel lines (Chen unpublished).

Yuping Chen, et al. Curr Drug Metab. ;10(6):567-578.

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