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1.
Fig. 3

Fig. 3. From: Lack of in vivo compartmentalization among HIV-1 infected na?ve and memory CD4+ T cell subsets.

Nucleotide distances among all subset comparisons. The horizontal bar depicts median values. N - Naïve; CM - CD57 memory; EM - CD57+ memory; S - Serum.

Edwin J. Heeregrave, et al. Virology. ;393(1):24-32.
2.
Fig. 4

Fig. 4. From: Lack of in vivo compartmentalization among HIV-1 infected na?ve and memory CD4+ T cell subsets.

Coreceptor usage of R5X4 clones from patient H671, 85 and 89 mpsc. U87.CD4 cells expressing either CCR5 or CXCR4 were infected with H671 R5X4 biological clones to determine coreceptor usage. Read-out was CA-p24 levels (ng/ml) in culture supernatant after seven days.

Edwin J. Heeregrave, et al. Virology. ;393(1):24-32.
3.
Fig. 1

Fig. 1. From: Lack of in vivo compartmentalization among HIV-1 infected na?ve and memory CD4+ T cell subsets.

Cellular infection levels. Each pie chart shows the relative infection levels of the naïve, CD57 memory and CD57+ memory subsets. For each patient, the relative number of LTR copies per 105 cells of one time-point is shown. For patients M11781 and M16394 infection levels for all subsets could not be determined.

Edwin J. Heeregrave, et al. Virology. ;393(1):24-32.
4.
Fig. 2

Fig. 2. From: Lack of in vivo compartmentalization among HIV-1 infected na?ve and memory CD4+ T cell subsets.

Neighbor-joining phylogenetic trees of patient M11814 9, 24 and 31 months after primary diagnosis. Env C2V3 sequences from the various cellular subsets and serum are represented by different symbols, as depicted in the legend. Reference strains are marked by diamonds and are shown at the bottom of each tree. For these bootstrap trees of 1,000 replicates, only bootstrap values higher than 80% are shown and the Kimura-2 parameter was used to calculate nucleotide distances.

Edwin J. Heeregrave, et al. Virology. ;393(1):24-32.
5.
Fig. 6

Fig. 6. From: Lack of in vivo compartmentalization among HIV-1 infected na?ve and memory CD4+ T cell subsets.

Longitudinal overview of the net env V3 charge distribution of HIV-1 variants isolated from different CD4+ compartments of patients H671 (A) and H434 (B). The relative quantity of the viruses within the naïve, CD57 memory, CD57+ memory and serum subsets and of the RCBCs is depicted on the y-axis and the net V3 charge is depicted on the x-axis. Time of sampling in months post seroconversion (mpsc) and the number of env variants analyzed are indicated above each panel. The CD57+ memory subset of 0.2 and 89 mpsc of patient H671 contains V3 clones from hyper-mutated viral variants, as indicated by asterisks.

Edwin J. Heeregrave, et al. Virology. ;393(1):24-32.
6.
Fig. 5

Fig. 5. From: Lack of in vivo compartmentalization among HIV-1 infected na?ve and memory CD4+ T cell subsets.

Longitudinal analysis of HIV-1 infection levels and size of CD4+ T cell subsets. (A, B) Cellular infection levels of patients H434 and H671 for the naïve, CD57 memory and CD57+ memory CD4+ T cell subsets are depicted on the left y-axis in number of gag copies per 105 cells as determined by qPCR. Serum viral load values are depicted in the same graph on the right y-axis. Time-points after coreceptor switch are marked with an asterisk. (C, D) Longitudinal overview of absolute CD4+ subset cell numbers in peripheral blood for patients H434 and H671.

Edwin J. Heeregrave, et al. Virology. ;393(1):24-32.

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