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Results: 6

1.
Figure 1

Figure 1. From: The Cardiovascular and Subjective Effects of Methamphetamine Combined with γ-vinyl-γ-aminobutyric acid (GVG) in Non-Treatment Seeking Methamphetamine-dependent Volunteers.

The Study Schema shows the entire 19-day inpatient procedure including titration schedule for GVG. The current report includes data obtained on Days 1-10, with emphasis on outcomes obtained during Day 10 methamphetamine infusion session. Data obtained on Days 12-17 include cue reactivity and self-administration and are being submitted for publication elsewhere.

Richard De La Garza, et al. Pharmacol Biochem Behav. ;94(1):186-193.
2.
Figure 6

Figure 6. From: The Cardiovascular and Subjective Effects of Methamphetamine Combined with γ-vinyl-γ-aminobutyric acid (GVG) in Non-Treatment Seeking Methamphetamine-dependent Volunteers.

Plasma levels of methamphetamine before and following two consecutive infusions of methamphetamine (15 mg + 30 mg, i.v.) as a function of drug (GVG or placebo) and time. Data represent the mean ± S.E.M. from only a subset (N=3 for GVG and N=4 for placebo) of methamphetamine-dependent participants on day 10.

Richard De La Garza, et al. Pharmacol Biochem Behav. ;94(1):186-193.
3.
Figure 4

Figure 4. From: The Cardiovascular and Subjective Effects of Methamphetamine Combined with γ-vinyl-γ-aminobutyric acid (GVG) in Non-Treatment Seeking Methamphetamine-dependent Volunteers.

Change in “Any Drug Effect” (upper panel), “High” (middle panel), or “Crave Methamphetamine” (lower panel) following two consecutive infusions of methamphetamine (15 mg + 30 mg, i.v.) as a function of drug (GVG or placebo) and time. Data represent the mean ± S.E.M. from 16 methamphetamine-dependent participants on day 10. Values represent change from baseline (given time-point minus t=−15 min).

Richard De La Garza, et al. Pharmacol Biochem Behav. ;94(1):186-193.
4.
Figure 2

Figure 2. From: The Cardiovascular and Subjective Effects of Methamphetamine Combined with γ-vinyl-γ-aminobutyric acid (GVG) in Non-Treatment Seeking Methamphetamine-dependent Volunteers.

Change in systolic blood pressure (upper panel), diastolic blood pressure (middle panel), or heart rate (lower panel) following two consecutive infusions of methamphetamine (15 mg + 30 mg, i.v.) as a function of drug (GVG or placebo) and time. Data represent the mean ± S.E.M. from 16 methamphetamine-dependent participants on day 10. Values represent change from baseline (given time-point minus t=−15 min).

Richard De La Garza, et al. Pharmacol Biochem Behav. ;94(1):186-193.
5.
Figure 5

Figure 5. From: The Cardiovascular and Subjective Effects of Methamphetamine Combined with γ-vinyl-γ-aminobutyric acid (GVG) in Non-Treatment Seeking Methamphetamine-dependent Volunteers.

Analysis of peak effects in “Any Drug Effect” (left), “High” (middle), or “Crave Methamphetamine” (right) following two consecutive infusions of methamphetamine (15 mg + 30 mg, i.v.) as a function of GVG dose (or placebo). Data represent the mean ± S.E.M. from 16 methamphetamine-dependent participants on day 10. Peak effect values represent change from baseline for a given time-point minus t=−15 min.

Richard De La Garza, et al. Pharmacol Biochem Behav. ;94(1):186-193.
6.
Figure 3

Figure 3. From: The Cardiovascular and Subjective Effects of Methamphetamine Combined with γ-vinyl-γ-aminobutyric acid (GVG) in Non-Treatment Seeking Methamphetamine-dependent Volunteers.

Analysis of peak effects in systolic blood pressure (left), diastolic blood pressure (middle), or heart rate (right) following two consecutive infusions of methamphetamine (15 mg + 30 mg, i.v.) as a function of GVG dose (or placebo). Data represent the mean ± S.E.M. from 16 methamphetamine-dependent participants on day 10. Peak effect values represent change from baseline for a given time-point minus t=−15 min.

Richard De La Garza, et al. Pharmacol Biochem Behav. ;94(1):186-193.

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