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Results: 4

1.
Figure 4

Figure 4. From: In-vivo imaging of retinal nerve fiber layer vasculature: imaging - histology comparison.

Comparison of in-vivo imaging and ex-vivo immunohistochemistry at two depths for images taken 5 mm temporal to the optic disc in monkey 1. Vessel branch points that can be seen in both the AO image and microscopy are indicated by arrowheads. Scalebars indicate 200 μm.

Drew Scoles, et al. BMC Ophthalmol. 2009;9:9-9.
2.
Figure 2

Figure 2. From: In-vivo imaging of retinal nerve fiber layer vasculature: imaging - histology comparison.

Epi-fluorescence micrographs of adjacent retinal sections from the inferior retina of monkey 1 (see Figure 1 for location) labeled for (A) axons-neurofilament - N 200 and (B) vasculature -CD31/vWF. The RPC and nerve fiber layer thickness shown in the lower half of Figure 1 were measured in such sections as illustrated in Figure 2 by the distance between the black arrows. Scalebar indicates 150 μm.

Drew Scoles, et al. BMC Ophthalmol. 2009;9:9-9.
3.
Figure 3

Figure 3. From: In-vivo imaging of retinal nerve fiber layer vasculature: imaging - histology comparison.

Through-focus series of in-vivo adaptive optics images of RPCs from two retinal locations in monkey 1 and one retinal location in monkey 2. One location in both monkeys is near the optic disc; monkey 1 (a, d, g, j) and monkey 2 (c, f, i, l) and the second is 5 mm temporal to the optic disc of monkey 1(b, e, h, k) (see Figure 1 for locations in monkey 1). At a focal plane deep within the NFL, a transition was found from RPC to to the typical, polygonal ganglion cell layer/retinal circulation (j, k, l). The focus depth set by the deformable mirror relative to the most superficial vasculature is displayed under each image. Scalebars indicate 200 μm.

Drew Scoles, et al. BMC Ophthalmol. 2009;9:9-9.
4.
Figure 1

Figure 1. From: In-vivo imaging of retinal nerve fiber layer vasculature: imaging - histology comparison.

Map of the location in the retina of monkey 1 where in-vivo images (heavy border squares) and RPC network thickness measures (dots) were made. The superior retina was prepared as a wholemount, but because this preparation compressed the tissue no measurements of radial peripapillary bed (RPC) or nerve fiber layer (NFL) thickness were made in this location. The lower retina was sectioned (fine dotted lines) parallel to the horizontal raphe (heavy dashed line). The ellipse shows the location of the optic disc and "x" represents the foveal location. Curving lines show the course of nerve fibers identified from fundus images. Numerical values for RPC network thickness and NFL thickness (in parentheses) were measured with ex-vivo confocal microscopy. In-vivo FAOSLO measures of thicknesses of the RPC network are shown in larger font numbers. RPC thickness in corresponding locations (thin border squares) in the lower retina are shown in italics. The heavy dotted line shows the location of the sections illustrated in Figure 2.

Drew Scoles, et al. BMC Ophthalmol. 2009;9:9-9.

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