Results: 4

1.
Figure 4

Figure 4. Changes in individual symptoms in Protocol #1. From: Propranolol decreases tachycardia and improves symptoms in the Postural Tachycardia Syndrome (POTS): Less is More.

The changes in the 9 individual components of the Vanderbilt POTS symptom score (in arbitrary units [au]) are presented from immediately before to 2 hours following study drug administration for propranolol 20mg (solid black) and placebo (black dots). A negative number represents an improvement in symptoms.

Satish R Raj, et al. Circulation. ;120(9):725-734.
2.
Figure 3

Figure 3. Change in symptoms with study medication. From: Propranolol decreases tachycardia and improves symptoms in the Postural Tachycardia Syndrome (POTS): Less is More.

The changes in the total Vanderbilt POTS symptom score (in arbitrary units [au]) are presented from immediately before to 2 hours following study drug administration. Panel A shows the changes for Protocol #1, with data for the propranolol 20mg day (solid black) and the placebo day (black dots) for the 36 subjects that completed symptom reporting for both interventions. Panel B shows the changes for Protocol #2, with data for the propranolol 20mg day (solid black) and the propranolol 80mg (checkered) for the 18 subjects. A negative score reflects a reduction in symptom burden. The error bars represent standard error of the mean. The P value was generated using a Wilcoxon rank-sum test.

Satish R Raj, et al. Circulation. ;120(9):725-734.
3.
Figure 1

Figure 1. Seated, standing and orthostatic changes in heart rates and blood pressures before and after propranolol 20mg vs. placebo (Protocol #1). From: Propranolol decreases tachycardia and improves symptoms in the Postural Tachycardia Syndrome (POTS): Less is More.

Heart rate (HR) and systolic blood pressure (SBP) data are presented immediately before (pre), and hourly for 4 hours (4H) following study drug administration for the propranolol 20mg day (“Prop 20”; solid circles) and the placebo day (open squares). Peak HR after standing for a maximum of 10 minutes (Fig 1A), seated HR immediately before standing (Fig 1B) and the changes in HR from sit to stand (Fig 1C) are shown in the top 3 panels. Similarly, the data for standing SBP (Fig 1D), seated SBP (Fig 1E) and the changes in SBP from sit to stand (Fig 1F) are shown in the bottom 3 panels. The error bars represent the standard error of the mean. The ANOVA P values are presented for the overall effect of the study drug over time. bpm – beats per minute; mmHg – millimeters of mercury.

Satish R Raj, et al. Circulation. ;120(9):725-734.
4.
Figure 2

Figure 2. Seated, standing and orthostatic changes in heart rates and blood pressures before and after Low Dose (20mg) Propranolol vs. High Dose (80mg) Propranolol (Protocol #2). From: Propranolol decreases tachycardia and improves symptoms in the Postural Tachycardia Syndrome (POTS): Less is More.

Heart rate (HR) and systolic blood pressure (SBP) data are presented immediately before (pre), and hourly for 4 hours (4H) following study drug administration for the propranolol 20mg day (“Prop 20”; solid circles) and the propranolol 80mg day (“Prop 80”; open triangles). Peak HR after standing for a maximum of 10 minutes (Fig 1A), seated HR immediately before standing (Fig 1B) and the changes in HR from sit to stand (Fig 1C) are shown in the top 3 panels. Similarly, the data for standing SBP (Fig 1D), seated SBP (Fig 1E) and the changes in SBP from sit to stand (Fig 1F) are shown in the bottom 3 panels. The error bars represent the standard error of the mean. The ANOVA P values are presented for the overall effect of the study drug over time. bpm – beats per minute; mmHg – millimeters of mercury.

Satish R Raj, et al. Circulation. ;120(9):725-734.

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