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1.
Figure 6

Figure 6. Systemic immune responses to i.p. OVA-immunization with OVA. From: Filaggrin deficient mice exhibit Th17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen.

(A) Serum levels of OVA-specific IgE and IgG1. (B) Cytokine secretion by splenocytes in response to OVA stimulation in vitro. *p<0.05, **p<0.01.

Michiko K. Oyoshi, et al. J Allergy Clin Immunol. ;124(3):485-493.e1.
2.
Figure 5

Figure 5. Systemic immune responses to EC sensitization with OVA. From: Filaggrin deficient mice exhibit Th17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen.

(A) Serum levels of OVA-specific IgE and IgG1. (B) Cytokine secretion by splenocytes in response to OVA stimulation in vitro. *p<0.05, **p<0.01, ***p<0.001.

Michiko K. Oyoshi, et al. J Allergy Clin Immunol. ;124(3):485-493.e1.
3.
Figure 3

Figure 3. Analysis of skin lesions in aged 32-week-old ft/ft mice. From: Filaggrin deficient mice exhibit Th17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen.

(A) Representative photomicrographs of H&E sections. (B) Numbers of CD4+ cells/HPF (400×). (C and D) Cytokine (C) and CXCL2 chemokine (D) mRNA expression. *p<0.05, **p<0.01, ***p<0.001.

Michiko K. Oyoshi, et al. J Allergy Clin Immunol. ;124(3):485-493.e1.
4.
Figure 1

Figure 1. Eczematous skin lesions and serum IgE and IgG1 levels in ft/ft mice. From: Filaggrin deficient mice exhibit Th17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen.

(A, B) Gross appearance of 4-, 8-, and 16-week-old ft/ft mice and 16-week-old C57BL6 (A) and of 32-week-old ft/ft mice (B). Arrows point to skin lesions. (C) Serum IgE and IgG1 levels in 8-, and 32-week-old ft/ft mice and 8 week-old BALB/c and C57BL6 mice. ***p<0.001.

Michiko K. Oyoshi, et al. J Allergy Clin Immunol. ;124(3):485-493.e1.
5.
Figure 4

Figure 4. Histology and cytokine expression of EC sensitized skin. From: Filaggrin deficient mice exhibit Th17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen.

(A) Representative photomicrographs of H&E sections of skin. (B) Epidermal thickness of OVA sensitized skin. Results are expressed as fold increase over saline sensitized skin. (C) Numbers of CD4+ cells/HPF (400×). (D) Cytokine mRNA expression. *p<0.05, **p<0.01, ***p<0.001.

Michiko K. Oyoshi, et al. J Allergy Clin Immunol. ;124(3):485-493.e1.
6.
Figure 2

Figure 2. Spontaneous Th17-dominated skin inflammation in 8 week-old ft/ft mice. From: Filaggrin deficient mice exhibit Th17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen.

(A) Representative photomicrographs of H&E sections. (B) Numbers of CD4+ cells/HPF (400×). (C) FACS analysis of CD3+CD4+ cells and CD11b+Gr-1+ neutrophils in ear skin. (D, E) Cytokine (D) and CXCL2 (E) mRNA expression in the skin. *p<0.05, **p<0.01, ***p<0.001.

Michiko K. Oyoshi, et al. J Allergy Clin Immunol. ;124(3):485-493.e1.

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