Results: 2

1.
Figure 1

Figure 1. From: Carney complex and lentiginosis.

A. Characteristic pigmentation in a patient with Carney complex; the lentigines are typically located on the eyelids and the inner canthi; a small myxoma is present on the upper eyelid (arrow); B. Genital macules in a patient with Carney complex; this are characteristic mucosal lesions in patients with the complex; C. multiple pigmented lesions, including blue nevy (arrow) on the face of a patient and D. subcutaneous myxoma on the back of the shoulder of a patient with Carney complex.

Anelia Horvath, et al. Pigment Cell Melanoma Res. ;22(5):580-587.
2.
Figure 2

Figure 2. From: Carney complex and lentiginosis.

Molecular pathways involved in lentiginosis – a cross talk. CNC, Carney complex; MAS, McCune Albright syndrome; PJS, Peutz-Jeghers syndrome; NS, Noonan syndrome; CD, Cowden disease; BRRS, Bannayan-Ruvalcaba-Riley syndrome; PIP2, phosphatidylinositol-3,4,5-triphosphate; PIP3, phosphatidylinositol-4,5-biphosphate; P13K, phosphoinositol kinase; PTEN, phosphatase and tensin homolog; TSC1 and TSC2, hamartin/tuberin complex; mTOR, mammalian target of rapamycin; AKT, v-akt murine thymoma viral oncogene homolog 1 [protein kinase B (PKB)]; AMPK, protein kinase; AMP, activated, beta 1 non-catalytic subunit; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; HRAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog; R, regulatory subunit of PKA; C, catalytic subunit of PKA.

Anelia Horvath, et al. Pigment Cell Melanoma Res. ;22(5):580-587.

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