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Results: 5

1.
Figure 2

Figure 2. Voxel-based morphometry. From: Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data.

Statistical parametric maps of grey and white matter differences among groups compared with controls. Data adjusted for age, sex, study site, and intracranial volume. Results are corrected for multiple comparisons using familywise error at the p<0·05 level.

Sarah J Tabrizi, et al. Lancet Neurol. ;8(9):791-801.
2.
Figure 3

Figure 3. Quantitative and oculomotor measures. From: Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data.

(A) Antisaccade error rate. (B) Static tongue force variability. (C) Self-paced tapping. (D) Gait as normal speed stance. Box plots: horizontal lines are median; boxes are upper and lower quartiles; bars are range; and dots are outliers. CV=coefficient of variance.

Sarah J Tabrizi, et al. Lancet Neurol. ;8(9):791-801.
3.
Figure 5

Figure 5. Problem behaviour assessment. From: Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data.

(A) PBA apathy score (frequency×severity). (B) PBA irritability score (frequency×severity; sum of irritability, anger/aggression and perseverative thinking/behaviour items). (C) PBA affect score (frequency×severity; sum of depressed mood, suicidal ideation, and anxiety items). Box plots: horizontal lines are median; boxes are upper and lower quartiles; bars are range; dots are outliers. PBA=problem behaviour assessment.

Sarah J Tabrizi, et al. Lancet Neurol. ;8(9):791-801.
4.
Figure 4

Figure 4. Cognitive measures. From: Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data.

(A) Recognition of facial expressions of negative emotions, scored as number correct out of 50. (B) Spot the change visual working memory Set Size 5 condition; “K” is the number correct, corrected for guessing (calculated as 5 [for the set size]×[the number of hits plus the number of correct rejections –1]. (C) University of Pennsylvania Smell Identification Test (number correct out of 20). Box plots: horizontal lines are median; boxes are upper and lower quartiles; bars are range; and dots are outliers.

Sarah J Tabrizi, et al. Lancet Neurol. ;8(9):791-801.
5.
Figure 1

Figure 1. Whole brain and regional atrophy in the controls, premanifest, and early Huntington’s disease groups. From: Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data.

(A) 3T volumetric MRI scan in a 50-year-old control, a 55-year-old individual with preHD, and a 49-year-old with early Huntington’s disease. Brain volumes are corrected for intracranial volume. (B) Brain volume as a percentage of intracranial volume across all groups (horizontal lines are median; boxes are upper and lower quartiles; bars are range; dots are outliers) and scatter plot of brain volume as a percentage of intracranial volume against disease burden. (C) Cortical thinning in the Huntington’s disease groups compared with controls. The top panel shows statistical maps corrected with the false discovery rate; magnitude maps are shown below. All results are adjusted for age and sex. ICV=intracranial volume. LH=left hemisphere. RH=right hemisphere.

Sarah J Tabrizi, et al. Lancet Neurol. ;8(9):791-801.

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