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Results: 2

1.
Figure 1

Figure 1. From: Circulating TGF? in Marfan's Syndrome.

Circulating TGFβ1 concentrations in Fbn1C1039G/+ and wild-type mice and their correlation with the aortic root size. (A) Mean total TGFβ1 serum concentrations showing increased concentrations with age, and significantly higher circulating total TGFβ1 levels in 6 to 10 month old Fbn1C1039G/+ mice compared to age-matched wild-types and losartan-treated Fbn1C1039G/+ mice. (B) Mean free TGFβ1 serum concentrations changed in the same manner as seen with total TGFβ1. A subgroup of Fbn1C1039G/+ mice was treated with a higher dose of losartan (1.2 g/l in drinking water instead of the 0.6 g/l standard dose) which resulted in a further reduction in circulating total and free TGFβ1 concentrations. (C) Correlation was observed between circulating total TGFβ1 concentrations and the sinus of Valsalva (SOV) diameters in untreated Fbn1C1039G/+ and wild-type mice (regression prediction lines with mean value and CI 95%). (D) Correlation was observed between free TGFβ1 concentrations and SOV size in untreated Fbn1C1039G/+ and wild-type mice (regression prediction lines with mean value and CI 95%).

Peter Matt, et al. Circulation. ;120(6):526-532.
2.
Figure 2

Figure 2. From: Circulating TGF? in Marfan's Syndrome.

Circulating total TGFβ1 concentrations in human samples, their correlation with z-scores in MFS patients, and the association with gender and age, respectively. (A) Mean total TGFβ1 plasma concentrations were elevated in MFS patients without cardiovascular drug therapy compared to healthy control individuals. MFS patients with losartan and/or β-blocker treatment showed a significant decrease in circulating total TGFβ1 levels compared to non-treated Marfans, and those with an ACEi therapy showed a tendency towards lower total TGFβ1 concentrations. *45 patients with combined losartan and β-blocker therapy; †10 patients with combined ACEi and β-blocker therapy (B) Correlation between circulating total TGFβ1 concentrations and z-scores in MFS patients without previous aortic root surgery was not significant (regression prediction lines with mean value and CI 95%). In addition, no significant correlation was observed in MFS patients without previous aortic surgery and no cardiovascular drug therapy (n=12, r=0.1, P=0.7). (C) Mean total TGFβ1 concentrations showed no significant difference between male and female in healthy control individuals and people with MFS. (D) No correlation was observed between total TGFβ1 concentrations and age in controls and those with MFS (r=0.3; r=0.07).

Peter Matt, et al. Circulation. ;120(6):526-532.

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