Results: 4

1.
Figure 1

Figure 1. From: Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland.

KIT immunohistochemical expression in primary adenoid cystic carcinoma of the salivary gland: (a) low-grade adenoid cystic carcinoma of the salivary gland with predominant cribriform/tubular pattern and (c) high-grade adenoid cystic carcinoma of the salivary gland with greater than 30% solid pattern with strong c-kit immunoreactivity in tumor cells (b, d). (a, b) Original magnification ×100; (c, d) magnification ×200.

Lizette Vila, et al. Mod Pathol. ;22(10):1296-1302.
2.
Figure 2

Figure 2. From: Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland.

KIT exon 11 mutational analyses in case of adenoid cystic carcinoma of the salivary gland. Multiple point mutations in exon 11 were detected in this case including Leu576Phe, similar to that described in gastrointestinal stromal tumors, novel mutations Pro551Leu and His580Tyr and a silent mutation in codon 578.

Lizette Vila, et al. Mod Pathol. ;22(10):1296-1302.
3.
Figure 4

Figure 4. From: Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland.

Adenoid cystic carcinoma of the salivary gland with KIT exon 17 point mutation Asn822Ser in hotspot region of codon 822. The wild-type KIT exon 17 sequence depicting codons 821–823 is illustrated on the left. On the right is a case of adenoid cystic carcinoma of the salivary gland with 2486A>G mutation, resulting in substitution of Asparagine for Serine in the frequently mutated c-kit region of codon 822.

Lizette Vila, et al. Mod Pathol. ;22(10):1296-1302.
4.
Figure 3

Figure 3. From: Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland.

Adenoid cystic carcinoma of the salivary gland with KIT exon 13 point mutation Val643Ala, similar to a variant mutation found in gastrointestinal stromal tumors. The chromatogram tracing on the left depicts a wild-type sequence of KIT exon 13, codons 642–644. On the right is a case of adenoid cystic carcinoma of the salivary gland with a point mutation 1949T>C in codon 643, resulting in substitution of Valine for Alanine.

Lizette Vila, et al. Mod Pathol. ;22(10):1296-1302.

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