We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 5

1.
Figure 3

Figure 3. From: The Transcriptional Response of the Islet to Pregnancy in Mice.

Temporal gene expression analysis of selected differentially expressed genes throughout pregnancy. A–R, Gene expression changes for each respective gene during d 10.5, d 14.5, and d 18.5 during pregnancy (n = 4–5 per time point; *, P < 0.05; #, P < 0.09).

Sebastian Rieck, et al. Mol Endocrinol. 2009 October;23(10):1702-1712.
2.
Figure 4

Figure 4. From: The Transcriptional Response of the Islet to Pregnancy in Mice.

Differentially expressed genes identified in the islet are expressed in ß-cells during pregnancy d 14.5. Gene expression changes for insulin (A) and Pdx1 (B) in wild-type liver, pregnant d 14.5 GFP− and pregnant day 14.5 GFP+ single-cell fractions. C–O, Gene expression levels of selected genes in pregnant d 14.5 GFP− compared with pregnant d 14.5 GFP+ single-cell fractions (n = 3 per fraction; *, P < 0.05).

Sebastian Rieck, et al. Mol Endocrinol. 2009 October;23(10):1702-1712.
3.
Figure 2

Figure 2. From: The Transcriptional Response of the Islet to Pregnancy in Mice.

Histological analysis of ß-cell proliferation, hypertrophy, and mass at d 14.5 during pregnancy. Insulin staining (A) and BrdU incorporation into ß-cells (C) of pregnant mice, insulin (B) and BrdU (D) staining of nonpregnant female mice, and BrdU staining of pregnant (E) and nonpregnant (F) mice (×20). Ki67 staining of pregnant (G), and nonpregnant (H) mice, dual fluorescent staining of cell surface marker E-cadherin (red) and insulin (green) of pregnant (I) and nonpregnant (J) mice.

Sebastian Rieck, et al. Mol Endocrinol. 2009 October;23(10):1702-1712.
4.
Figure 1

Figure 1. From: The Transcriptional Response of the Islet to Pregnancy in Mice.

ß-Cell proliferation with ß-cell hypertrophy dramatically increase ß-cell mass at d 14.5 of pregnancy in mice. A, ß-Cell mass of nonpregnant and pregnant (d 14.5) mice (n = 3–4/group; *, P < 0.05 vs. nonpregnant control). Quantification of (B) BrdU-positive cells per islet (n = 4–5; *, P < 0.03 vs. control), (C) BrdU-positive cells as % of total nuclei (n = 4–5; *P < 0.01 vs. control), and (D) percentage of islets with certain number of BrdU-positive cells. Determination of (E) ß-cell size and (F) percentage of islets with certain ß-cell size (n = 4–5; *, P < 0.05 vs. control). Gene expression changes (G) of cell cycle regulators (n = 4–5; *, P < 0.05 vs. control). AU, Arbitrary units; pos., positive.

Sebastian Rieck, et al. Mol Endocrinol. 2009 October;23(10):1702-1712.
5.
Figure 5

Figure 5. From: The Transcriptional Response of the Islet to Pregnancy in Mice.

Gene expression profiles differ between the pregnancy, obesity, and ß-cell injury models of ß-cell regeneration. A, Strain-dependent comparison of mRNA expression of both mKi67 and Birc5 between both 4- and 10-wk-old B6ob/ob and BTBRob/ob leptin-deficient mice and lean controls (n = 5–7 per strain; *, P < 0.05 vs. respective lean control; #, P = 0.055; $, P = 0.08). B, Expression of selected differentially expressed genes identified in the pregnancy paradigm during obesity at 10 wk in the B6 strain (n = 5–7 per strain; *, P < 0.05 vs. lean control; &, not detectable). C, Temporal gene expression of mKi67 and Birc5 before (d 0), after (d 30), and during (d 8) recovery from chemically induced ß-cell ablation. D and E, Temporal gene expression of selected pregnancy-induced genes during recovery from chemically induced ß-cell ablation in the PANIC-ATTAC model (n = 4–5 per time point; *, P < 0.05 vs. day 0).

Sebastian Rieck, et al. Mol Endocrinol. 2009 October;23(10):1702-1712.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk