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Results: 5

1.
Figure 1

Figure 1. From: Genetic Loci Influencing C-reactive Protein Levels and Risk of Coronary Heart Disease.

Manhattan plot of results from the combined analysis of genome-wide association data (9 cohorts)

Paul Elliott, et al. JAMA. ;302(1):37-48.
2.
Figure 5

Figure 5. From: Genetic Loci Influencing C-reactive Protein Levels and Risk of Coronary Heart Disease.

Associations of SNPs in LEPR (rs6700896), IL6R (rs4537545), HNF1A (rs1183910) loci and APOE-CI-CII (rs4420638) cluster in the genetic association study with CHD. Effects are given as Odds Ratios (95% Confidence Intervals) per copy of minor allele

Paul Elliott, et al. JAMA. ;302(1):37-48.
3.
Figure 2

Figure 2. From: Genetic Loci Influencing C-reactive Protein Levels and Risk of Coronary Heart Disease.

Results of Mendelian randomisation experiment of rs7553007 in the CRP locus (present study), with rs1130864 and rs1205 from published studies, with CHD, among 28,112 cases and 100,823 controls. Effects are given as Odds Ratios (95% Confidence Intervals) per 20% lower CRP

Paul Elliott, et al. JAMA. ;302(1):37-48.
4.

Figure 3. From: Genetic Loci Influencing C-reactive Protein Levels and Risk of Coronary Heart Disease.

Meta-analysis of associations of SNPs rs1130864 and rs1205 with CRP levels, CRP levels with CHD, and SNPs with CHD, in prospective studies where all three analyses have been reported. (a) Associations of SNPs rs1130864 and rs1205 with CRP levels. Effects are given as % change (95% Confidence Intervals) per minor allele (rs1205) and per major allele (rs1130864). (b) Associations of CRP levels with CHD. Effects are given as Odds Ratios (95% Confidence Intervals) per 20% lower CRP. (c) Associations of SNPs rs1130864 and rs1205 with CHD. Effects are given as Odds Ratios (95% Confidence Intervals) per 20% lower CRP

Paul Elliott, et al. JAMA. ;302(1):37-48.
5.
Figure 4

Figure 4. From: Genetic Loci Influencing C-reactive Protein Levels and Risk of Coronary Heart Disease.

Meta-analysis of the relationship of CRP levels with CHD from prospective observational studies. Effects are given as Odds Ratios (95% Confidence Intervals) per 20% lower CRP
Footnote to Figure 4.
Random effects estimate presented in Figure, fixed effects estimate: OR 0.951 (95% CI, 0.945-0.957). For cohort studies, number of ‘controls’ represents the number of event-free individuals. Number of controls was not available for ARIC (Ref 65).
*Case-cohort **Cohort ***Nested case-control

Paul Elliott, et al. JAMA. ;302(1):37-48.

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