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Results: 3

1.
Figure 1

Figure 1. Ube3a deficiency results in morphological changes of mitochondria in mouse hippocampal CA1 neurons. From: Mitochondrial dysfunction in CA1 hippocampal neurons of the Ube3a deficient mouse model for Angelman syndrome.

Electron micrographs of wild-type littermate (WT, A) and m-\p+ mouse (B). Magnification: ×8900. Black arrows show mitochondria and white arrows indicate small, electron- dense spheroids within mitochondria. C) Cumulative probability curves of a distribution of mitochondrial sizes in the m-\p+ mice and their WT. X-axis indicates mitochondrial size and Y-axis indicates cumulative fraction.

Hailing Su, et al. Neurosci Lett. ;487(2):129-133.
2.
Figure 2

Figure 2. Ube3a deficiency leads to decrease in enzyme activities of brain mitochondrial complex III. From: Mitochondrial dysfunction in CA1 hippocampal neurons of the Ube3a deficient mouse model for Angelman syndrome.

The enzyme activities of the brain (A) and hippocampal (B) mitochondrial complexes. An inserted chart in A is enlarged for complexes II+III. The data were normalized with citrate synthase. Measurements were repeated 3 times for each test on each animal. * p<0.05 (Student t test, M±SD). Empty bars indicate WT; Black bars indicate the m-\p+ mice. C) Western blotting analysis of mitochondrial complexes II and III is shown in upper panel, and porin staining in lower panel. The arrows indicate complexes II, III and porin on the right, and genotypes of mice are shown above.

Hailing Su, et al. Neurosci Lett. ;487(2):129-133.
3.
Figure 3

Figure 3. Ube3a deficiency results in reduction of synaptic vesicle density in hippocampal CA1 neurons. From: Mitochondrial dysfunction in CA1 hippocampal neurons of the Ube3a deficient mouse model for Angelman syndrome.

Electron micrographs of chemical synapses in WT (A) and m-\p+ mouse (B). Magnification: ×8900. C) Analysis of synaptic vesicle density. ** p<0.01 (Student t test, M±SD). D) Western blotting analysis using synaptophysin (SYP) (upper panel) and an actin-specific antibody (lower panel) in the m-\p+ mice and their WT brains. The arrows indicate SYP and actin on the right. E) Densitometic analysis of SYP expression in the m-\p+ mice and their WT brains. Y-axis indicates relative values of SYP vs WT (%) and X-axis indicates genotypes of mice.

Hailing Su, et al. Neurosci Lett. ;487(2):129-133.

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