Results: 5

1.
Figure 5

Figure 5. From: Decreased connectivity and cerebellar activity in autism during motor task performance.

Sectional maps and illustration demonstrating differences in functional connectivity between HFA and TD children. The thickness of the lines represents the magnitude of the difference in standard errors (differences of < 1 SEM are not shown).

Stewart H. Mostofsky, et al. Brain. 2009 September;132(9):2413-2425.
2.
Figure 2

Figure 2. From: Decreased connectivity and cerebellar activity in autism during motor task performance.

Charts showing results of RHFS (upper chart) and LHFS (lower chart) with bar graphs representing mean percent signal change (± SEM) compared with rest for children with autism (blue) and TD controls (red) in ROIs derived from the individual group maps (Fig. 1). **P < 0.05, Bonferroni-corrected for multiple comparisons; *P < 0.1, Bonferroni-corrected for multiple comparisons.

Stewart H. Mostofsky, et al. Brain. 2009 September;132(9):2413-2425.
3.
Figure 1

Figure 1. From: Decreased connectivity and cerebellar activity in autism during motor task performance.

Glass brain and sectional maps showing regions where fMRI activation was significantly associated with LHFS (left images) and RHFS (right images), each contrasted with rest, for TD children (upper images) and children with autism (lower images). All maps were thresholded at P = 0.05 corrected for multiple comparisons. Neurologic convention is used (i.e. right = right hemisphere; projections looking rightward or into the page).

Stewart H. Mostofsky, et al. Brain. 2009 September;132(9):2413-2425.
4.
Figure 3

Figure 3. From: Decreased connectivity and cerebellar activity in autism during motor task performance.

Sectional maps showing localization of differences in fMRI activation between children with autism and TD children during RHFS (red), LHFS (blue), and the overlap between RHFS and LHFS (pink). The upper maps show regions where TD children showed greater activation than did those with autism; the lower maps show regions where children with autism showed greater activation than did TD children. The results are based on a Gaussian random effects analysis of each group of 13 participants; all maps were thresholded at P = 0.05 uncorrected for multiple comparisons. Representative slices are shown in the sagittal (left hemisphere), coronal and axial planes. Neurologic convention is used (i.e. right = right hemisphere; projections looking rightward or into the page).

Stewart H. Mostofsky, et al. Brain. 2009 September;132(9):2413-2425.
5.
Figure 4

Figure 4. From: Decreased connectivity and cerebellar activity in autism during motor task performance.

Bar graphs demonstrating differences in functional connectivity between HFA and TD children. The legend in the grey box explains how information is presented. Within the triangle as a whole, the six boxes in the top-left portion represent connectivity between region-pairs in left-handed (L) motor circuits (e.g. right motor cortex, left cerebellum), the six boxes in the bottom-right portion represent connectivity between region-pairs in right-handed (R) motor circuits (e.g. left motor cortex, right cerebellum), and the nine boxes in the top-right represent connectivity between region-pairs in hand-neutral (N) motor circuits (e.g. right motor cortex, left motor cortex). Within each box, the three plots, from left to right, represent connectivity between the region pair during rest (left), RHFS (middle) and LHFS (right), respectively; children with HFA are shown in red and TD children are show in blue. Also within each box, the y-axis represents normalized r-values, and the axis ranges from 0 to 2; standard deviation bars are shown. Labels at the top and left of the figure demonstrated the region-pairs examined in each box (R = right; L = left; M1 = primary motor cortex; cer = anterior cerebellum; thal = thalamus).

Stewart H. Mostofsky, et al. Brain. 2009 September;132(9):2413-2425.

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