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Results: 5

1.
Figure 4

Figure 4. From: Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/MR-Imaging.

Drug and dye release profiles of functional IONPs (5) in PBS (pH = 7.4) at 37 °C. Release of Taxol (A & B) and DiI (C & D) were observed in the presence of an esterase enzyme (A & C) and at pH 4.0 (B & D).

Santimukul Santra, et al. Small. ;5(16):1862-1868.
2.
Figure 2

Figure 2. From: Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/MR-Imaging.

Determination of cytotoxicity of the functional IONPs: carboxylated [COOH (2)], propargylated [PROPARGYL (3)], folate-conjugated [FOLATE (4)] and Taxol-carrying [TAXOL (5)]. Control (CTRL) cells: A) Lung carcinoma cells (A549) and B) Cardiomyocyte cells (H9c2) were treated with PBS. Average values of four measurements are depicted ± standard error.

Santimukul Santra, et al. Small. ;5(16):1862-1868.
3.
Scheme 1

Scheme 1. From: Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/MR-Imaging.

Schematic representation of the synthesis of theranostics and multimodal IONPs. Click chemistry and carbodiimide chemistry have been used for the synthesis of a library of functional IONPs. Near IR dyes- and paclitaxel co-encapsulated IONPs were prepared in water using the modified solvent diffusion method (See Supporting Information 1 and 2 for detailed synthetic procedures).

Santimukul Santra, et al. Small. ;5(16):1862-1868.
4.
Figure 3

Figure 3. From: Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/MR-Imaging.

Assessment of IONPs’ cellular uptake via confocal laser-scanning microscopy using lung carcinoma A549 cells. A) No internalization was observed in cells treated with carboxylated IONPs (2), as no DiI fluorescence was observed in the cytoplasm, B) Enhanced internalization was observed upon incubation with the folate-immobilized IONPs (4), C) Cells incubated with Taxol and DiI co-encapsulating folate-functionalized IONPs (5) induced cell death. (D–F) Corresponding merged confocal images of the functional IONPs treated cells with their nucleus stained with DAPI (blue).

Santimukul Santra, et al. Small. ;5(16):1862-1868.
5.
Figure 1

Figure 1. From: Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/MR-Imaging.

Characterization of multimodal nanoparticles 2 (PAA-IONP-DiI). A) Determination of hydrodynamic diameter of the IONPs through Dynamic Light Scattering (DLS), Inset: Transmission Electron Microscope (TEM) image of the corresponding nanoparticles. Scale bar 100 nm. B) magnetic hysteresis loops at 300 and 5 K, showing nanoparticles are superparamagnetic C) fluorescence emission spectra (in PBS buffer) of DiI dye encapsulated IONPs 2 and that of 1 without any dye, D) fluorescence emission spectra of 2 and that of free non-encapsulated DiI in solution.

Santimukul Santra, et al. Small. ;5(16):1862-1868.

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