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Results: 4

1.
Figure 3

Figure 3. From: Simvastatin Protects against the Development of Endometriosis in a Nude Mouse Model.

Effects of simvastatin on the number and volume of lesions per mouse; each bar represents mean ± sem. Means with no superscripts in common are significantly different (P < 0.05). The figure summarizes three separate experiments on 37 mice: 13 in the control group, 12 treated with simvastatin at 5 mg/kg, and 12 treated with simvastatin at 25 mg/kg.

Kaylon L. Bruner-Tran, et al. J Clin Endocrinol Metab. 2009 July;94(7):2489-2494.
2.
Figure 1

Figure 1. From: Simvastatin Protects against the Development of Endometriosis in a Nude Mouse Model.

Gross (A–E) and microscopic (F–J, hematoxylin and eosin staining) photomicrographs of experimental endometriosis established by proliferative phase human endometrium in nude mice. All mice were implanted with a slow-release estradiol capsule before introduction of human tissues. Mice were killed 4 h to 10 d after human tissue injection. Results are representative of three separate experiments using three different human biopsies. Original magnification: gross, ×15; microscopic, ×40.

Kaylon L. Bruner-Tran, et al. J Clin Endocrinol Metab. 2009 July;94(7):2489-2494.
3.
Figure 2

Figure 2. From: Simvastatin Protects against the Development of Endometriosis in a Nude Mouse Model.

Gross morphology of experimental endometriosis established by proliferative phase human endometrium in nude mice. All mice were implanted with a slow-release estradiol capsule before introduction of human tissues. Mice were treated by gavage with vehicle (A), 5 mg/kg simvastatin (B), or 25 mg/kg simvastatin (C). D–F, Hematoxylin and eosin stains of tissues from each treatment group (D, vehicle; E, 5 mg/kg simvastatin; and F, 25 mg/kg simvastatin). Results are representative of three separate experiments using three different human biopsies. Original magnification: ×100. Arrows point to endometrial implants.

Kaylon L. Bruner-Tran, et al. J Clin Endocrinol Metab. 2009 July;94(7):2489-2494.
4.
Figure 4

Figure 4. From: Simvastatin Protects against the Development of Endometriosis in a Nude Mouse Model.

Western analysis of expression and regulation of MMP-3 protein in human endometrial stromal cells isolated from proliferative phase endometrial biopsies (n = 5). Cells were cultured for 48 h in the presence of estradiol (E, 1 nm), followed by an additional 24 h with E alone or E plus simvastatin (Sim) at 1 or 10 μm. Some cultures were also exposed to IL-1α during the last 6 h of culture. A representative experiment is shown in top panel. Densitometric analysis of all studies is shown in bottom panel. *, Means significantly different from control; †, means significantly different from IL-1α.

Kaylon L. Bruner-Tran, et al. J Clin Endocrinol Metab. 2009 July;94(7):2489-2494.

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