Results: 3

1.
Figure 2

Figure 2. Genome scans for four expression phenotypes. From: Genetic analysis of radiation-induced changes in human gene expression.

The chromosomal location of the target gene is given in parentheses. a, Example of 2-h-after-irradiation expression phenotypes. b, Example of 6-h-after-irradiation expression phenotypes.

Denis A. Smirnov, et al. Nature. ;459(7246):587-591.
2.
Figure 3

Figure 3. Results of knockdown of five regulators of radiation-expression phenotypes. From: Genetic analysis of radiation-induced changes in human gene expression.

Regulators of expression levels of radiation-responsive genes were knocked down by siRNAs. Changes in expression levels of the regulators and their corresponding target genes after knockdown of the regulators are shown, as are changes in expression levels of a control gene (encoding glyceraldehyde-3-phosphate dehydrogenase) after knockdown of the regulators. Data are shown as means ± s.e.m. for four or more independent transfections. Asterisk, P < 0.05; two asterisks, P = 0.07; no symbol, P > 0.05.

Denis A. Smirnov, et al. Nature. ;459(7246):587-591.
3.
Figure 1

Figure 1. Individual variation in gene expression response to ionizing radiation. From: Genetic analysis of radiation-induced changes in human gene expression.

Fold change in 11 radiation-responsive genes; data for each individual are shown as a circle (open circles for 2-h-after-irradiation expression phenotypes; filled circles for 6-h-after-irradiation expression phenotypes). TRIAP1 (TP53-regulated inhibitor of apoptosis 1) is shown as an example of a gene that showed little individual variation in response to ionizing radiation. Other genes show extensive individual variation in gene expression.

Denis A. Smirnov, et al. Nature. ;459(7246):587-591.

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