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1.
Figure 1

Figure 1. From: A compact VEGF signature associated with distant metastases and poor outcomes.

Kaplan-Meier survival plots. Kaplan-Meier survival plots according to MetScore status (A and B) and according to intrinsic subtype (C and D) across the 146 patient UNC training data set.

Zhiyuan Hu, et al. BMC Med. 2009;7:9-9.
2.
Figure 3

Figure 3. From: A compact VEGF signature associated with distant metastases and poor outcomes.

In situ hybridization. In Situ hybridization to localize gene transcripts using a representative tumor for A) Adrenomedulin (ADM), B) Angiopoetin-like 4 (ANGPLT4), and C) Vascular Endothelial Growth Factor A (VEGF). Magnification 200×.

Zhiyuan Hu, et al. BMC Med. 2009;7:9-9.
3.
Figure 6

Figure 6. From: A compact VEGF signature associated with distant metastases and poor outcomes.

H&E images of a primary breast tumor taken from a MetScore 3 patient. Showing a prominent admixed stromal component comprised of fibroblasts and myofibroblasts in the primary tumor. The fibroblast/myofibroblast component is markedly diminished in the distant metastatic sites (B and C) as compared with the primary tumor (A). Magnification 200×.

Zhiyuan Hu, et al. BMC Med. 2009;7:9-9.
4.
Figure 4

Figure 4. From: A compact VEGF signature associated with distant metastases and poor outcomes.

Univariate Kaplan-Meier survival plots. Univariate Kaplan-Meier survival plots of survival for patients stratified using the VEGF profile on the A) UNC training data set, B) NKI test data set, C) Bhattacharjee et al lung carcinoma data set [29], and D) Nutt et al glioblastoma data set [30]. Note: two genes ANGPTL4 and C14ORF58 were not found on Affymetrix platforms for C and D.

Zhiyuan Hu, et al. BMC Med. 2009;7:9-9.
5.
Figure 5

Figure 5. From: A compact VEGF signature associated with distant metastases and poor outcomes.

VEGF profile, glycolysis and HIF1α gene expression analyses. A) Gene expression for the VEGF profile (plus average values), for the six glycolysis genes and glycolysis centroid, HIF1α and fibroblast centroids are shown across the 146 patient UNC training data set with the tumors ordered according to their VEGF profile average values. B) Similar analysis as presented in A except the data set is the NKI patient test set.

Zhiyuan Hu, et al. BMC Med. 2009;7:9-9.
6.
Figure 2

Figure 2. From: A compact VEGF signature associated with distant metastases and poor outcomes.

One-way average linkage hierarchical cluster analysis. One-way average linkage hierarchical cluster analysis of the gene set associated with MetScore status. One hundred and ninety-five microarrays, representing 146 tumors and 10 normal breast samples were analyzed using the 1195 gene MetScore gene set. Overview of the complete cluster diagram (the full cluster diagram can be found as Additional file 2). The tumors were ordered according to their MetScore, and then according to their increasing correlation to the Metscore3 centroid within each group. Clinical regional node status, distant metastasis status, ER, PR, and intrinsic subtype are shown. A) FOS-JUN gene expression cluster, B) fibroblast/mesenchymal cell cluster, C) CXCL12 gene expression cluster, D), immune-cell/HLA cluster, E) VEGF profile.

Zhiyuan Hu, et al. BMC Med. 2009;7:9-9.

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