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1.
Figure 6

Figure 6. From: A reexamination of information theory-based methods for DNA-binding site identification.

Information profile for P. aeruginosa Fur and H. influenzae CRP motifs. (A) Rsequence and RE profiles for Fur on the P. aeruginosa genome. (B) Rsequence and RE profiles for CRP on the H. influenzae genome, and for the mean Rsequence profile obtained from 10,000 45-site subsamples of the 210 E. coli binding sites. Vertical bars show the standard deviation.

Ivan Erill, et al. BMC Bioinformatics. 2009;10:57-57.
2.
Figure 5

Figure 5. From: A reexamination of information theory-based methods for DNA-binding site identification.

Search efficiency for CRP sites in E. coli and H. influenzae. ROC curves for search methods trying to locate H. influenzae and E. coli CRP binding sites on, respectively, H. influenzae and E. coli genomes. Abbreviations: Eco – E. coli, Hin – H. influenzae. The plot is scaled to encompass a 1/10 true to false positive ratio (450 false positives) in H. influenzae.

Ivan Erill, et al. BMC Bioinformatics. 2009;10:57-57.
3.
Figure 4

Figure 4. From: A reexamination of information theory-based methods for DNA-binding site identification.

Search efficiency for Fur sites in E. coli and P. aeruginosa. ROC curves for search methods trying to locate P. aeruginosa and E. coli Fur binding sites on, respectively, P. aeruginosa and E. coli genomes. Abbreviations: Eco – E. coli, Hin – H. influenzae. The plot is scaled to encompass a 1/10 true to false positive ratio (320 false positives) in P. aeruginosa.

Ivan Erill, et al. BMC Bioinformatics. 2009;10:57-57.
4.
Figure 9

Figure 9. From: A reexamination of information theory-based methods for DNA-binding site identification.

Search efficiency in E. coli with "weakened" CRP sites. Mean ROC curves for the Ri search method trying to locate CRP binding sites on the E. coli genome, using the original, asymmetric and mirrored collections of CRP. The plot is scaled to encompass a 1/10 true to false positive ratio for CRP (2100 false positives). The Rsequence profile of the original, asymmetrical and mirrored CRP motifs is shown in the inset.

Ivan Erill, et al. BMC Bioinformatics. 2009;10:57-57.
5.
Figure 1

Figure 1. From: A reexamination of information theory-based methods for DNA-binding site identification.

Search efficiency in the E. coli genome. ROC curves for different IT-based binding site search methods attempting to locate known LexA, Fur, CRP and Fis sites on the E. coli genome. The plot is scaled to encompass a 1/10 true to false positive ratio for the transcription factor with the largest number of known sites (CRP; 210 sites). Vertical arrows indicate this same ratio for all transcription factors.

Ivan Erill, et al. BMC Bioinformatics. 2009;10:57-57.
6.
Figure 8

Figure 8. From: A reexamination of information theory-based methods for DNA-binding site identification.

Standard and effective affinity range for different transcription factors. (a) Estimation of the affinity range for the different transcription factors analyzed in this work. For each transcription factor, the affinity range is represented as the distribution of affinities for all its experimentally determined binding sites. The affinity of each binding site is estimated using the Rsequence · BvH ranking index. (b) Estimation of the effective affinity range. For each transcription factor, the effective affinity range is represented as the distribution of normalized affinities for all its experimentally determined binding sites. Normalized affinities are estimated by normalizing the Rsequence · BvH ranking index for each site with the number of false positives required to find that site. For comparison purposes, in both affinity range plots Rsequence · BvH values (Y-axis) are normalized to the length of the binding motif for each transcription factor and ranges (X-axis) are shown as the percentage of experimentally determined sites (collection).

Ivan Erill, et al. BMC Bioinformatics. 2009;10:57-57.
7.
Figure 2

Figure 2. From: A reexamination of information theory-based methods for DNA-binding site identification.

Search efficiency for E. coli CRP sites in a skewed random background. ROC curves for search methods trying to locate 210 CRP binding sites on randomly generated backgrounds. The ROC curve depicts the mean and standard deviation of three independent experiments (searches against three independently genrerated backgrounds). The plot is scaled to encompass a 1/10 true to false positive ratio (2100 false positives) in the equiprobable background. RE' results, which completely overlap RE · BvH ones, are not shown for clarity. The RE profiles for CRP against the different backgrounds are shown in the bottom-right inset.

Ivan Erill, et al. BMC Bioinformatics. 2009;10:57-57.
8.
Figure 3

Figure 3. From: A reexamination of information theory-based methods for DNA-binding site identification.

Search efficiency for E. coli Fur sites in a skewed random background. ROC curves for search methods trying to locate 45 Fur binding sites on randomly generated backgrounds. The ROC curve depicts the mean and standard deviation of three independent experiments (searches against three independently genrerated backgrounds). The plot is scaled to encompass a 1/10 true to false positive ratio (450 false positives) in the equiprobable background. RE' results, which completely overlap RE · BvH ones, are not shown for clarity. The RE profiles for Fur against the different backgrounds are shown in the bottom-right inset.

Ivan Erill, et al. BMC Bioinformatics. 2009;10:57-57.
9.
Figure 7

Figure 7. From: A reexamination of information theory-based methods for DNA-binding site identification.

Observed vs. expected frequency of 20-mers in genomes. Mean ratio between observed and expected 20-mers in real genomes versus randomly generated sequences. Ratios were computed independently for 3 different genomes and 3 random sequences of similar %GC composition. Vertical bars show the standard deviation of these ratios. Genomes used for calculations: E. coli str. K-12 substr. MG1655 [50.8% GC], P. aeruginosa PAO1 [66.6% GC], H. influenzae Rd KW20 [38.1% GC], Colwellia psychrerythraea 34H [38.0% GC], Salinibacter ruber DSM 13855 [66.2% GC], Thiobacillus denitrificans ATCC 25259 [66.1% GC], Enterococcus faecalis V583 [37.5% GC], Anaplasma marginale str. St. Maries [49.8% GC] and Nitrosococcus oceani ATCC 19707 [50.3% GC].

Ivan Erill, et al. BMC Bioinformatics. 2009;10:57-57.

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