We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 5

1.
Figure 4

Figure 4. From: Re-evaluating Dorsolateral Prefrontal Cortex Activation During Working Memory in Schizophrenia.

Analysis of functional activation (percent change in BOLD signal ± standard error) in each group, calculated by pooling across the activation observed at each subjects individually calculated working memory capacity (Equation 1).

Katherine H. Karlsgodt, et al. Schizophr Res. ;108(1-3):143-150.
2.
Figure 5

Figure 5. From: Re-evaluating Dorsolateral Prefrontal Cortex Activation During Working Memory in Schizophrenia.

DLPFC performance-activation data from the current first episode sample and previously analyzed chronic sample (Karlsgodt, 2007) demonstrating the replicability of the cross-over pattern in these two samples.

Katherine H. Karlsgodt, et al. Schizophr Res. ;108(1-3):143-150.
3.
Figure 2

Figure 2. From: Re-evaluating Dorsolateral Prefrontal Cortex Activation During Working Memory in Schizophrenia.

Behavioral performance (percent correct ± standard error) on the verbal working memory task across memory load (number of letters presented). The patient group is divided at the median to constitute “low performing” and “high performing” subgroups.

Katherine H. Karlsgodt, et al. Schizophr Res. ;108(1-3):143-150.
4.
Figure 3

Figure 3. From: Re-evaluating Dorsolateral Prefrontal Cortex Activation During Working Memory in Schizophrenia.

Between-subjects linear regression investigating the relationship in working memory performance (percent correct) and functional activation (percent change in BOLD signal ± standard error) in patient and control groups in left (A) and right (C) DLPFC. Within-subjects functional activation across working memory load in left (B) and right (D) DLPFC ROIs. All subject groups demonstrate similar functions, however high performing patients are hyperactive to controls while low performing patients are hypoactive. Functionally defined regions of interest in left and right DLPFC (E).

Katherine H. Karlsgodt, et al. Schizophr Res. ;108(1-3):143-150.
5.
Figure 1

Figure 1. From: Re-evaluating Dorsolateral Prefrontal Cortex Activation During Working Memory in Schizophrenia.

Proposed model: 1a. Inverted-U shaped curve representing the hypothetical signal change in DLPFC as a response to increasing working memory load in patients with schizophrenia and controls (Callicott et al, 2003; Manoach, 2003), 1b Between-subjects crossover model (based on Karlsgodt, 2007), plotting individual differences in overall performance (averaged across the entire task) against individual differences in overall functional activation (averaged across the entire task), 1c Proposed Multi-level model. Each inverted curve shaped function represents the change in activation of an individual subject as load changes. The placement of the curves is determined by individual differences in performance, which influence the range of activation within which the subject changes. As a group, controls increase activation as performance decreases, while patients do the opposite. Independently of this, all subjects show similar functions of activation changes with load.

Katherine H. Karlsgodt, et al. Schizophr Res. ;108(1-3):143-150.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk