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Results: 5

1.
Figure 5

Figure 5. From: Variation in Oxytocin Receptor Density in the Nucleus Accumbens has Differential Effects on Affiliative Behaviors in Monogamous and Polygamous Voles.

Receptor autoradiography illustrating OTR binding density in the NAcc of CMV-OTR (A) and CMV-GFP (B) meadow voles. Note that CMV-GFP female meadow voles had little or no OTR binding in the NAcc. However, OTR binding in the NAcc was dramatically elevated in CMV-OTR female meadow voles. Bar = 1mm.

Heather E. Ross, et al. J Neurosci. ;29(5):1312-1318.
2.
Figure 4

Figure 4. From: Variation in Oxytocin Receptor Density in the Nucleus Accumbens has Differential Effects on Affiliative Behaviors in Monogamous and Polygamous Voles.

Partner preference behavior of female meadow voles after a 24 hr co-habitation (A) and after a culmulative 72 hour co-habitation (B). CMV-OTR and CMV-GFP injected females did not show a partner preference. They spent equal amounts of time with the partner and the stranger at both time points. Data are presented as mean ± SEM.

Heather E. Ross, et al. J Neurosci. ;29(5):1312-1318.
3.
Figure 1

Figure 1. From: Variation in Oxytocin Receptor Density in the Nucleus Accumbens has Differential Effects on Affiliative Behaviors in Monogamous and Polygamous Voles.

Alloparental behavior in sham, CMV-GFP and CMV-OTR female prairie voles. A) There was no effect of treatment on the proportion of females in each treatment group that displayed alloparental behavior. The dark bars represent the percent of animals that were categorized as alloparental, while the light bars depict the number of females that attacked or ignored the pups. B) The latency to approach pups was not different between groups. C) There was no difference between groups in the amount of time the females spent licking pups, when only the females in each group that displayed alloparental behavior towards the pups were compared. Data are presented as mean ± SEM.

Heather E. Ross, et al. J Neurosci. ;29(5):1312-1318.
4.
Figure 3

Figure 3. From: Variation in Oxytocin Receptor Density in the Nucleus Accumbens has Differential Effects on Affiliative Behaviors in Monogamous and Polygamous Voles.

Analysis of OTR and GFP expression in CMV-OTR and CMV-GFP female prairie voles. OTR density was determined using receptor autoradiography. A, B) There was significant variation in the density of OTR binding in the NAcc of CMV-GFP females. This is in contrast to the prefrontal cortex (PFC), where there is little individual variation in OTR binding density. Bar = 1mm. C) CMV-OTR injected females had elevated OTR binding in the NAcc relative to controls. D) The dark square surrounding the NAcc depicts the position of the photomicrograph in E, shNAcc = shell of the NAcc, ac = anterior commissure. E) Photomicrograph taken using a 20x objective of GFP-immunoreactivity in the shell of the NAcc of a CMV-GFP female. Immunoreactivity was distributed widely in soma as well as fiber processes. F) Higher magnification photomicrograph of the image in E illustrating the clear neuronal characteristics of the GFP-immunoreactive cells. Bars in E and F = 50 μm.

Heather E. Ross, et al. J Neurosci. ;29(5):1312-1318.
5.
Figure 2

Figure 2. From: Variation in Oxytocin Receptor Density in the Nucleus Accumbens has Differential Effects on Affiliative Behaviors in Monogamous and Polygamous Voles.

Mating and partner preference behavior in sham, CMV-GFP, and CMV-OTR female prairie voles. The latency to first intromission (A) and the number of mating bouts (B) were not significantly different between the groups. C) After a 6 hour cohabitation period, none of the groups displayed a significant preference for the partner over the stranger. D) After a cumulative 18 hour cohabitation, CMV-OTR injected females spent significantly more time with the partner than the stranger (p<.001). The sham and CMV-GFP injected females did not spend significantly more time with either male at either time point. E) Scatter plot illustrating the ratio of the time spent with partner/stranger for each individual in the groups. Females spending greater than 67% of their total social contact time with the partner (above the dashed line) are considered to have displayed a partner preference. F) The overall percentage of animals in each group that displayed a partner preference. Data are presented as mean ± SEM.

Heather E. Ross, et al. J Neurosci. ;29(5):1312-1318.

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