Figure 1

Figure 1. From: Regulation of different inflammatory diseases by impacting the mevalonate pathway.

Inhibition of the l-mevalonate pathway for immunomodulation. Statins interfere with 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme of the l-mevalonate pathway which causes reduction of farnesylated and geranylgeranylated downstream proteins. Besides others, the GTPases Ras, Rho-B and Rap-1 that play a role in the process of activation and proliferation of T cells are not prenylated, which affects their binding to the T-cell membrane. This shift in active GTPase signalling is connected to a blockade of T helper type 1 (Th1) cytokine production.

Robert Zeiser, et al. Immunology. 2009 May;127(1):18-25.

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