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Results: 8

1.
F <span style="font-variant: small-caps" class="small-caps">ig</span> . 1.

F ig . 1. From: Characterization of the Disposition and Toxicokinetics of N-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2.

Chemical structure of NBuPy-Cl (CAS 1124-64-7). Asterisk indicates the location of the radiolabeled 14C.

Y. Cheng, et al. Drug Metab Dispos. 2009 April;37(4):909-916.
2.
F <span style="font-variant: small-caps" class="small-caps">ig</span> . 8.

F ig . 8. From: Characterization of the Disposition and Toxicokinetics of N-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2.

Kinetics of TEA (A) and NBuPy-Cl (B) transport in the CHO cells (○) and CHO_hOCT2 cells (•) and inhibition of TEA transport by NBuPy-Cl (C) in CHO_hOCT2 cells (•). A, Kt(TEA) = 27.1 ± 7.3 μM. B, Kt(NBuPy-Cl) = 17.6 ± 3.0 μM. C, IC50(NBuPy-Cl) = 2.3 ± 0.6 μM. Data are expressed as mean ± S.E.M.; n = 3.

Y. Cheng, et al. Drug Metab Dispos. 2009 April;37(4):909-916.
3.
F <span style="font-variant: small-caps" class="small-caps">ig</span> . 7.

F ig . 7. From: Characterization of the Disposition and Toxicokinetics of N-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2.

Time course of NBuPy-Cl (5 mg/kg; A) and inulin (0.67 mg/kg; B) in blood plasma after intravenous coadministration of [14C]NBuPy-Cl and [3H]inulin to male F-344 rats. Data are expressed as mean ± S.E.M.; n = 4. Predicted values (dash lines) were calculated based on best-fit analyses using two-compartment model fit.

Y. Cheng, et al. Drug Metab Dispos. 2009 April;37(4):909-916.
4.
F <span style="font-variant: small-caps" class="small-caps">ig</span> . 6.

F ig . 6. From: Characterization of the Disposition and Toxicokinetics of N-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2.

Time course of NBuPy-Cl in blood after intravenous (5 mg/kg, n = 7, closed circle) and oral (50 mg/kg, n = 8, open circle) administration of [14C]NBuPyCl to male F-344 rats. Data are expressed as mean ± S.E.M. Predicted values (dash lines) were calculated based on best-fit analyses using two-compartment model fit for intravenous and one-compartment model fit for oral.

Y. Cheng, et al. Drug Metab Dispos. 2009 April;37(4):909-916.
5.
F <span style="font-variant: small-caps" class="small-caps">ig</span> . 2.

F ig . 2. From: Characterization of the Disposition and Toxicokinetics of N-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2.

Cumulative excretion of radioactivity after a single administration of [14C]NBuPy-Cl (♦ total, ▾ urine, • feces). Data are expressed as mean ± S.E.M. A, intravenous administration (5 mg/kg) to male F-344 rats (n = 7); B, oral administration (50 mg/kg) to male F-344 rats (n = 8); C, oral administration (50 mg/kg) to female B6C3F1 mice (n = 6).

Y. Cheng, et al. Drug Metab Dispos. 2009 April;37(4):909-916.
6.
F <span style="font-variant: small-caps" class="small-caps">ig</span> . 3.

F ig . 3. From: Characterization of the Disposition and Toxicokinetics of N-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2.

Cumulative excretion of radioactivity after serial daily oral administration of [14C]NBuPy-Cl (50 mg/kg/day) to male F-344 rats. Data are expressed as mean ± S.E.M.; n = 4 per dosing group. Open symbols, 1 dose; closed symbols, 1 dose/day for 5 days; ⋄/♦, total; ▿/▾, urine; ○/•, feces; stepwise line, total cumulative dose.

Y. Cheng, et al. Drug Metab Dispos. 2009 April;37(4):909-916.
7.
F <span style="font-variant: small-caps" class="small-caps">ig</span> . 5.

F ig . 5. From: Characterization of the Disposition and Toxicokinetics of N-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2.

Representative radiochromatograms of urine and blood samples. A, [14C]NBuPy-Cl standard. B, urine samples from male F-344 rats at 6 h (dash-dot line) and female B6C3F1 mice at 12 h (solid line) after a single oral administration of [14C]NBuPy-Cl (50 mg/kg). C, blood samples at 7.5 min after a single intravenous administration of [14C]NBuPy-Cl (5 mg/kg, dash-dot line) and at 90 min after a single oral administration of [14C]NBuPy-Cl (50 mg/kg, solid line) to male F-344 rats.

Y. Cheng, et al. Drug Metab Dispos. 2009 April;37(4):909-916.
8.
F <span style="font-variant: small-caps" class="small-caps">ig</span> . 4.

F ig . 4. From: Characterization of the Disposition and Toxicokinetics of N-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2.

Dermal application of [14C]NBuPy-Cl (5 mg/kg) to male F-344 rats in three different vehicles. DMF, DMF/water vehicle (55:45, v/v); EtOH, ethanol/water vehicle (55:45, v/v); water, water vehicle. Data are expressed as mean ± S.E.M.; n = 3 per dosing group. A, cumulative excretion of radioactivity in urine and feces over 96 h. B, absorbed (14C recovered from urine, feces, and tissues) and unabsorbed (14C recovered from skin wash, skin stripping, and trap) [14C]NBuPy-Cl at 96 h.

Y. Cheng, et al. Drug Metab Dispos. 2009 April;37(4):909-916.

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