Results: 4

1.
Figure 4

Figure 4. From: Genetic Linkage Localizes an Adolescent Idiopathic Scoliosis and Pectus Excavatum Gene to the 18q Chromosome.

Frequency of pectus excavatum in AIS family members. AIS patients were selected randomly from a tertiary referral center for scoliosis and a detailed family history was obtained, specifically asking for evidence of connective tissue disorders, including pectus excavatum.

Christina A Gurnett, et al. Spine (Phila Pa 1976). ;34(2):E94-100.
2.
Figure 3

Figure 3. From: Genetic Linkage Localizes an Adolescent Idiopathic Scoliosis and Pectus Excavatum Gene to the 18q Chromosome.

Pedigree showing haplotype consisting of a 6.6cM (7.3 Mb) region of chromosome 18q12.1–q12.2 shared among all individuals affected with scoliosis or pectus excavatum (red bar). Individuals with scoliosis are shaded black. Individuals with pectus excavatum are shaded black and indicated with an asterisk. The proband is indicated with an arrowhead. Critical recombinants are indicated by arrows. Brackets enclose haplotypes that were inferred.

Christina A Gurnett, et al. Spine (Phila Pa 1976). ;34(2):E94-100.
3.
Figure 2

Figure 2. From: Genetic Linkage Localizes an Adolescent Idiopathic Scoliosis and Pectus Excavatum Gene to the 18q Chromosome.

Genome-wide linkage analysis of family 6061. (A) Two-point linkage analysis considering individuals with AIS and PE as affected was performed assuming autosomal dominant inheritance with penetrance of 80%, phenocopy rate of 1%, and disease allele frequency of 0.1%. (B) Multipoint linkage analysis considering individuals with AIS and PE as affected using the same parameters as above. Analysis was performed with marker sets of 100. (C) Multipoint linkage analysis considering individuals with AIS as affected using the same parameters.

Christina A Gurnett, et al. Spine (Phila Pa 1976). ;34(2):E94-100.
4.

Figure 1. From: Genetic Linkage Localizes an Adolescent Idiopathic Scoliosis and Pectus Excavatum Gene to the 18q Chromosome.

Clinical photos of family members. A, Photograph of proband (age 12 years) before undergoing posterior spinal fusion for progressive idiopathic scoliosis. B. Anteroposterior upright spinal radiograph of proband before spinal fusion demonstrating a 75 degree main right thoracic curve. C, Photograph of proband’s sister (age 9 years) demonstrating pectus deformity.

Christina A Gurnett, et al. Spine (Phila Pa 1976). ;34(2):E94-100.

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