Results: 4

1.
Figure 1

Figure 1. From: Dose-dependent Inhibition of Tobacco Smoke Carcinogen-induced Lung Tumorigenesis in A/J Mice by Indole-3-carbinol.

Experimental design to assess inhibition of NNK plus BaP-induced lung tumorigenesis in A/J mice by I3C.

Fekadu Kassie, et al. Cancer Prev Res (Phila). ;1(7):10.1158/1940-6207.CAPR-08-0064.
2.
Figure 3

Figure 3. From: Dose-dependent Inhibition of Tobacco Smoke Carcinogen-induced Lung Tumorigenesis in A/J Mice by Indole-3-carbinol.

Effect of I3C on food consumption (A) and body weight gain (B) of female A/J mice.

Fekadu Kassie, et al. Cancer Prev Res (Phila). ;1(7):10.1158/1940-6207.CAPR-08-0064.
3.
Figure 2

Figure 2. From: Dose-dependent Inhibition of Tobacco Smoke Carcinogen-induced Lung Tumorigenesis in A/J Mice by Indole-3-carbinol.

HPLC analysis of I3C-supplemented AIN-93 mouse diet. A, I3C standard; B, I3C-supplemented diet kept at 4 °C for one month; C, I3C-supplemented diet kept in the mouse feeders in the open for four days; D, DIM standard

Fekadu Kassie, et al. Cancer Prev Res (Phila). ;1(7):10.1158/1940-6207.CAPR-08-0064.
4.
Figure 4

Figure 4. From: Dose-dependent Inhibition of Tobacco Smoke Carcinogen-induced Lung Tumorigenesis in A/J Mice by Indole-3-carbinol.

Effect of I3C on cell proliferation and apoptosis. A, Photomicrographs (x 20) of Ki-67-and phospho-Akt-stained lung tissues from mice treated with vehicle control, NNK plus BaP or the carcinogens and I3C. Lung tissues obtained from Experiment 1 (groups 1, 7 and 9) were cut into 4 μm sections and stained with Ki-67 or phospho-Akt antibody and counterstained with hematoxylin. Images were captured with a camera attached to a Nikon Eclipse E800 microscope. B, Western immunoblots of lung tissues. Whole lung tissues obtained from Experiment 2 or normal lung tissues (group 9) and microdissected tumors (groups 1 and 7) from Experiment 1 were prepared as described in Materials and Methods and equal amounts of protein were loaded onto a 4-12% SDS-PAGE followed by immunoblot analysis and chemiluminescence detection. Equal loading of protein was confirmed by stripping the immunoblot and reprobing it for β-actin.

Fekadu Kassie, et al. Cancer Prev Res (Phila). ;1(7):10.1158/1940-6207.CAPR-08-0064.

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