Results: 3

1.
Figure 2.

Figure 2. From: Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case–control study.

Prevalence of rare MC4R (A) and MC3R (B) mutation carriers in severely obese and lean subjects. Prevalence of carriers is determined by combining both Cohort I and Cohort II (a total of 889 cases and 932 controls). The prevalence of total rare mutation case carriers was compared with control carriers. These mutations were then grouped according to results of the functional studies. Comparison of carriers between cases and controls were made using two-tailed Fisher's exact test. **P < 0.005; NS, not significant.

Melissa A. Calton, et al. Hum Mol Genet. 2009 March 15;18(6):1140-1147.
2.
Figure 3.

Figure 3. From: Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case–control study.

Functional analysis of mutant MC3Rs. α-MSH dose–response curves of mutants identified in (A) lean controls of Cohorts I and II (n = 932) and (B) severely obese cases of Cohorts I and II (n = 889). Data points represent mean ± SEM of at least three experiments performed in triplicate. Mean (CI95%) of the EC50 (nm) is indicated for each variant, when the variant response reached a maximum. For comparison purposes, the activities range from basal activity (0%) to the maximal activity (100%) of each receptor.

Melissa A. Calton, et al. Hum Mol Genet. 2009 March 15;18(6):1140-1147.
3.
Figure 1.

Figure 1. From: Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case–control study.

Functional analysis of mutant MC4Rs. α-MSH dose–response curves of mutants identified in (A) lean controls of Cohort I (n = 554), (B) severely obese cases of Cohort I (n = 510), (C) lean controls of Cohort II (n = 378) and (D) severely obese cases of Cohort II (n = 379). Data points represent mean ± SEM of at least three experiments performed in triplicate. Mean (CI95%) of the EC50 (nm) is indicated for each variant, when the variant response reached a maximum. For comparison purposes, the activities range from basal activity (0%) to the maximal activity (100%) of each receptor.

Melissa A. Calton, et al. Hum Mol Genet. 2009 March 15;18(6):1140-1147.

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