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Results: 4

1.
Fig. 1.

Fig. 1. From: CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit.

Antibody responses to NY-ESO-1 before and after anti-CTLA-4 antibody therapy. Reciprocal antibody titers against Escherichia coli-derived NY-ESO-1 protein were measured by ELISA and are shown for each available time point as indicated. Antibody titers below 100 were defined as negative. Five NY-ESO-1 seropositive patients are shown, while the other 10 patients are NY-ESO-1 seronegative.

Jianda Yuan, et al. Proc Natl Acad Sci U S A. 2008 December 23;105(51):20410-20415.
2.
Fig. 4.

Fig. 4. From: CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit.

Polyfunctional NY-ESO-1 antigen-specific T cells secreted higher levels of IFN-γ after anti-CTLA-4 antibody treatment. (A) IFN-γ fluorescence of CD4+ (Top) and CD8+ (Bottom) T cells with different functional properties before and after anti-CTLA-4 antibody treatment. Representative example from patient IMF-8. (B) Compiled IFN-γ MFI of CD4+ T cells of different cytokine combinations.

Jianda Yuan, et al. Proc Natl Acad Sci U S A. 2008 December 23;105(51):20410-20415.
3.
Fig. 2.

Fig. 2. From: CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit.

NY-ESO-1 specific CD4+ and CD8+ T cell responses were induced after CTLA-4 blockade. Representative intracellular cytokine and chemokine staining of both CD4+ and CD8+ T cells responding to NY-ESO-1 pooled peptides from NY-ESO-1 seropositive patient IMF-8 at weeks 1 and 12. Single cytokine gates were set based on negative control (unstimulated) samples and were placed consistently across samples (Bottom).

Jianda Yuan, et al. Proc Natl Acad Sci U S A. 2008 December 23;105(51):20410-20415.
4.
Fig. 3.

Fig. 3. From: CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit.

CTLA-4 blockade induced T cell responses are polyfunctional. NY-ESO-1 specific T cells secrete MIP-1β and IFN-γ (A), or TNF-α and IFN-γ (B). Samples scored as positive are indicated with * over week1 baseline. (C) Functional composition of the CD4+ T cell response. All possible combinations of three function responses are shown on the x axis. Responses are grouped and color-coded. (D) Each slice on the pie charts represents the fraction of the total response that is CD4+ T cell positive for a given number of functions; (Top) calculated from five clinical non-responders, (Bottom) from eight patients with evidence of clinical benefit.

Jianda Yuan, et al. Proc Natl Acad Sci U S A. 2008 December 23;105(51):20410-20415.

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