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Results: 2

1.
Figure 1

Figure 1. From: Effect of abstinence challenge on brain function and cognition in smokers differs by COMT genotype.

Visual N-back median reaction time difference scores. Median reaction time difference scores (N-back minus 0-back) for all responses show significant differences between the three genotype groups (Wald χ2(2) = 7.05, P = 0.03). Within the val/val group, there is a significant decrease in average response time during the smoking session for the 3-back condition, compared to abstinence.

J Loughead, et al. Mol Psychiatry. ;14(8):820-826.
2.
Figure 2

Figure 2. From: Effect of abstinence challenge on brain function and cognition in smokers differs by COMT genotype.

Visual N-back working memory task activation. (a) Mean activation for abstinent and smoking sessions identified by a parametric model of increased working memory load (P≤0.05, corrected). Brain rendering performed with CARET.49 (b) Mean percent signal change (N-back minus 0-back) for the 1-back, 2-back and 3-back contrasts calculated from a priori regions of interest. Abstinence effects differed among the three genotype groups (Wald χ2(2) = 15.06, P = 0.0005).

J Loughead, et al. Mol Psychiatry. ;14(8):820-826.

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