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1.
Figure 3

Figure 3. From: Molecular Biology of Head & Neck Cancer: Risks and Pathways.

Molecular pathways contributing to the promotion and progression of tumorigenesis in head and neck cancer.

Michael E. Stadler, et al. Hematol Oncol Clin North Am. ;22(6):1099-1124.
2.
Figure 1

Figure 1. Diversity of Head & Neck Cancer. From: Molecular Biology of Head & Neck Cancer: Risks and Pathways.

Histopathologic diagnoses that present at the various subsites in the head and neck.

Michael E. Stadler, et al. Hematol Oncol Clin North Am. ;22(6):1099-1124.
3.
Figure 2

Figure 2. Genetic progression of HNSCC. From: Molecular Biology of Head & Neck Cancer: Risks and Pathways.

Genetic changes associated with the histological progression of HNSCC based on loss of chromosomal material (allelic loss). Genetic alterations have been placed prior to the lesion where the frequency of the particular event plateaus. It is the accumulation and not necessarily the order of genetic events that determines the progression. A small fraction of benign squamous hyperplastic lesions contain 9p21 or 3p21 loss, suggesting that an unidentified precursor lesion (or cells) may also give rise to dysplasia. Candidate tumor suppressor genes include p16 (9p21), p53 (17p), and retinoblastoma (13q), and a candidate proto-oncogene includes cyclin D1 (11q13). (figure taken and adapted with permission from Califano.)

Michael E. Stadler, et al. Hematol Oncol Clin North Am. ;22(6):1099-1124.

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