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Results: 4

1.
Figure 3.

Figure 3. From: UCbase & miRfunc: a database of ultraconserved sequences and microRNA function.

Function page. It provides tables showing ultraconserved elements properties (enhancer activity, alternative splicing, splicing NMD regulation and transcription evidence) and miRNA ‘experimentally proved’ function.

Cristian Taccioli, et al. Nucleic Acids Res. 2009 January;37(Database issue):D41-D48.
2.
Figure 4.

Figure 4. From: UCbase & miRfunc: a database of ultraconserved sequences and microRNA function.

Sequence comparison page. This page allows the researchers to match selected sequences against miRNAs and ultraconserved elements (exact/500/1000/2000/5000/10 000 bp up/downstream). Checking the parsing option it is possible to turn the output into a single-line summary (blue arrow).

Cristian Taccioli, et al. Nucleic Acids Res. 2009 January;37(Database issue):D41-D48.
3.
Figure 1.

Figure 1. From: UCbase & miRfunc: a database of ultraconserved sequences and microRNA function.

Multi-queries text box (red square). Multiple queries can be performed typing the names of selected miRNAs or UCRs and obtaining as output the band, the gene name, the coordinates, the human diseases related to the band and the secondary structure up to 500 bp up/downstream.

Cristian Taccioli, et al. Nucleic Acids Res. 2009 January;37(Database issue):D41-D48.
4.
Figure 2.

Figure 2. From: UCbase & miRfunc: a database of ultraconserved sequences and microRNA function.

Search Page. miRNA and UCRs information can be retrieved searching for band, human Mendelian inheritance disorders related to that band or just typing the name of a gene (red highlighted boxes). The use of an interactive map of biological systems and diseases allows to link miRNAs and ultraconserved sequences to the related disorders (blue arrow).

Cristian Taccioli, et al. Nucleic Acids Res. 2009 January;37(Database issue):D41-D48.

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