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Results: 3

1.
Figure 1

Figure 1. From: Genetically Hypertensive Brown Norway Congenic Rat Strains Suggest Intermediate Traits Underlying Genetic Hypertension.

Genetic maps superimposed on the genomic sequence of rat chromosomes 2, 6, and 18 with blood pressure quantitative trait loci (BP QTL), congenic regions, and flanking markers. Checker board filled lines represent introgressed BP QTL regions, horizontal bars are flanking markers used to construct the congenics. It is important to note that these congenics were generated long before there was genomic sequence to firmly establish genetic order or genetic distances. The brackets denote the mapped QTL (99% confidence interval).

Marijo Bilušić, et al. Croat Med J. 2008 October;49(5):586-599.
2.
Figure 2

Figure 2. From: Genetically Hypertensive Brown Norway Congenic Rat Strains Suggest Intermediate Traits Underlying Genetic Hypertension.

Blood pressure response to norepinephrine (NE) x-axis shows different concentration of administered drugs as follows: 1 = 0.1 μg/kg/min, 2 = 0.2 μg/kg/min, 3 = 0.5 μg/kg/min, and 4 = 1.0 μg/kg/min. y-axis shows calculated mean delta mean arterial pressure value between 10th and 15th minute of infusion. BN.GH2 (n = 11) – doted line, BN.GH6 (n = 11) – full line, BN.GH18 (n = 11) – dasehs line, and BN (n = 14) – bold line. Lines represent linear regression lines (slopes) for each group. All data were evaluated by analysis of variance (ANOVA) with a post-hoc analysis using Dunnett test (multiple comparisons vs control BN group).

Marijo Bilušić, et al. Croat Med J. 2008 October;49(5):586-599.
3.
Figure 3

Figure 3. From: Genetically Hypertensive Brown Norway Congenic Rat Strains Suggest Intermediate Traits Underlying Genetic Hypertension.

Blood pressure response to angiotensin II (ANGII). x-axis shows different concentration of administered drugs as follows: 1 = 5 ng/kg/min, 2 = 10 ng/kg/min, 3 = 25 ng/kg/min, and 4 = 50 ng/kg/min. y-axis shows calculated mean delta mean arterial pressure (MAP) value between minutes 10 and 15 of infusion. BN.GH2 (n = 11) – dashed line, BN.GH6 (n = 11) – full line, BN.GH18 (n = 11) – doted line, and BN (n = 14) – bold line. Lines represent linear regression lines (slopes) for each group. MAP responses to ANGII were significantly enhanced in BN.GH2 and BN.GH18 rats compared with control. P < 0.05 BN.GH2 vs BN; P < 0.05 BN.GH18 vs BN. All data were evaluated by analysis of variance (ANOVA) with a post-hoc analysis using Dunnett test (multiple comparisons vs control BN group).

Marijo Bilušić, et al. Croat Med J. 2008 October;49(5):586-599.

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